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- W1569784300 abstract "Clinically, infant care is challenging especially in resource-poor developing countries where small-for-gestational-age is common and in any country when an infant is born prematurely. Several components comprise perinatal mortality of infants. Children suffering from vitamin A deficiency have a greater risk of irreversible blindness and dying from infectious diseases. Supplementation programs are an approach to address this issue. Studies have found little or no improvement in infant vitamin A status after supplementing with 25,000 IU vitamin A. Based on WHO’s recommendations, children ages 6 - 11 mo receive 100,000 IU vitamin A and those 12 - 59 mo receive 200,000 IU vitamin A every 4 to 6 mo. Multi-centered and randomized trials of infant supplementation programs have shown inconsistent results. Infant supplementation itself has been debated due to the higher incidence of bulging fontanelle in vitamin A-dosed infants. Therefore, a series of studies were performed in a swine model to evaluate infant dosing regimens. Newborn piglets from vitamin A-depleted sows received a placebo, 25,000, 50,000, or 200,000 IU vitamin A supplements at birth. Tissues were collected and analyzed. The degree of vitamin A deficiency did not seem to affect the response to treatment. High doses may be quickly catabolized to maintain balance. Lung and spleen require chylomicron vitamin A to maintain concentrations, which was confirmed with a tracer study using α-retinol. The tracer study also showed quick uptake in the adrenal gland. Low birth weight piglets took up less vitamin A. Food sources of vitamin A performed better than supplementation at improving vitamin A status of offspring. Grant Funding Source: Supported by the Nutrition Unit at the World Health Organization." @default.
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- W1569784300 date "2014-04-01" @default.
- W1569784300 modified "2023-09-23" @default.
- W1569784300 title "Mechanistic studies in swine to evaluate newborn infant vitamin A dosing strategies (260.1)" @default.
- W1569784300 doi "https://doi.org/10.1096/fasebj.28.1_supplement.260.1" @default.
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