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- W1569785027 abstract "Publisher Summary This chapter describes how lipoproteins are transported from the plasma compartment to cells of the body. The lipoproteins rely heavily on the apoproteins associated with their surface coat for correct targeting of lipoproteins to the sites of metabolism. Apoproteins mediate the interaction of lipoprotein particles with enzymes and cell surface receptors. The metabolism of low-density lipoprotein (LDL) via the LDL receptor is the best understood system. The pathways of mammalian lipoprotein metabolism can be divided into exogenous and endogenous branches that deal with the transport of dietary and hepatically derived lipids, respectively. Both metabolic sequences start with the production and secretion of triglyceride-(TG)rich lipoproteins. Despite significant advancements, the mechanism for chylomicron remnant removal needs further attention. Efforts to develop preventive and/or curative gene therapy are preceded by extensive studies in transgenic animals that overexpress apolipoproteins, enzymes involved in lipid metabolism, or the LDL receptor. Thus, these various approaches discussed in the chapter can be expected to extend to genes that are directly involved in all stages of atherogenesis." @default.
- W1569785027 created "2016-06-24" @default.
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- W1569785027 date "1991-01-01" @default.
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- W1569785027 title "Chapter 16 Removal of lipoproproteins from plasma" @default.
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- W1569785027 doi "https://doi.org/10.1016/s0167-7306(08)60344-0" @default.
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