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• W1569789076 abstract "ABSTRACT Objectives To compare the value of Doppler surveillance with maternal blood angiogenic factors at diagnosis for the prediction of adverse outcome in late‐pregnancy small‐for‐gestational‐age ( SGA ) fetuses. Methods In a cohort of 198 SGA fetuses we evaluated the association of Doppler indices (mean uterine artery pulsatility index ( UtA‐PI ) and cerebroplacental ratio ( CPR )) and angiogenic factors (maternal serum levels of soluble fms‐like tyrosine kinase‐1 ( sFlt ‐1) and placental growth factor ( PlGF )) with the development of pre‐eclampsia and adverse perinatal outcome (operative delivery for non‐reassuring fetal status or neonatal metabolic acidosis). Results In SGA fetuses subsequently developing pre‐eclampsia, mean UtA‐PI ( P < 0.001), sFlt ‐1 MoM ( P < 0.001) and sFlt ‐1/ PlGF MoM ratio ( P < 0.001) were higher, while PlGF MoM was lower ( P = 0.004). In SGA fetuses with adverse perinatal outcome, CPR ( P < 0.002) and PlGF MoM ( P < 0.001) were lower, and sFlt ‐1/ PlGF MoM ratio was higher ( P = 0.001). For predicting pre‐eclampsia, the areas under the receiver–operating characteristics ( ROC ) curves for mean UtA‐PI , sFlt ‐1 MoM and the combination of both were 0.852, 0.839 and 0.860, respectively. For adverse perinatal outcome, the areas under the ROC curves for CPR , PlGF MoM and the combination of both were 0.652, 0.656 and 0.684, respectively. The combination of Doppler indices and angiogenic factors did not significantly improve prediction of either pre‐eclampsia ( P = 0.851) or adverse outcome ( P = 0.579). Conclusions In SGA fetuses, angiogenic factors at diagnosis and follow‐up with Doppler ultrasound both predict adverse outcome with a similar performance. Copyright © 2013 ISUOG. Published by John Wiley & Sons Ltd." @default.
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• W1569789076 date "2014-03-27" @default.
• W1569789076 modified "2023-10-06" @default.
• W1569789076 title "Angiogenic factors<i>vs</i>Doppler surveillance in the prediction of adverse outcome among late-pregnancy small-for- gestational-age fetuses" @default.
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• W1569789076 doi "https://doi.org/10.1002/uog.13246" @default.
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