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- W1569791315 abstract "Lactonisation of the stereoisomeric N-(carboxymethyl)-4-phenyl-4-ethylpyrrolidin-3-ols (10a and b) as well as of the corresponding methyl (9) and ethyl (7) esters and of their 3-acetates (11) afforded the bicyclic lactone, 6-phenyl-6-ethyl-1-aza-4-oxabicyclo[3.2.1]octan-3-one (12). Reductive cyclization of N-(carbethoxymethyl)-2-phenyl-2-ethylpyrrolidin-3-one oxime (23) yielded the bicyclic lactam, 8-phenyl-8-ethyl-1, 4-diazabicyclo[3.2.1]octan-3-one (24). The structures assigned to these bicyclic compounds as well as to the various pyrrolidine derivatives have been substantiated by chemical means and by the interpretation of their NMR spectra." @default.
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- W1569791315 date "1972-01-01" @default.
- W1569791315 modified "2023-10-17" @default.
- W1569791315 title "Bridged bicyclic compounds" @default.
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- W1569791315 doi "https://doi.org/10.1016/s0040-4020(01)93552-5" @default.
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