FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569792304> ?p ?o ?g. }

• W1569792304 endingPage "81" @default.
• W1569792304 startingPage "4776" @default.
• W1569792304 abstract "The telomerase enzyme is a reverse transcriptase capable of replacing the telomeric DNA sequences that are lost at each cell division. Telomerase activation permits extended cell proliferation beyond normal senescence checkpoints, and accordingly, telomerase activity has been detected in a wide range of malignant cells and tissues but is absent in terminally differentiated somatic cells. To date, the majority of cancer-related telomerase analyses have been performed on carcinomas that originate from epithelial cells, and few reports have included tumors originating from nonepithelial cells. In this study, we used the PCR-based telomeric repeat amplification protocol (TRAP) to assay telomerase activity in nuclear protein extracts obtained from a range of malignant and benign connective tissue lesions. In total, 62 histologically diagnosed specimens were analyzed including 37 sarcomas, 7 benign mesenchymal tumors, 12 normal tissue samples, and 6 carcinoma metastases obtained from bone. Thirty (81%) of the 37 primary sarcoma samples contained telomerase activity, and four of the six carcinoma metastases were also positive. Conversely, telomerase activity was detectable in only one of seven benign lesions and in none of the 12 normal connective tissue controls. Tumors of connective tissue origin can sometimes be difficult to categorize and to evaluate microscopically with regard to clinical management. As is the case in carcinomas, the presence of telomerase activity appears to be indicative of malignancy in mesenchymal tumor biopsy material and therefore may be useful as an adjunct to the pathologist in the assessment of borderline cases." @default.
• W1569792304 created "2016-06-24" @default.
• W1569792304 creator A5013769942 @default.
• W1569792304 creator A5029365885 @default.
• W1569792304 creator A5040297156 @default.
• W1569792304 creator A5040870373 @default.
• W1569792304 creator A5056801490 @default.
• W1569792304 creator A5081166185 @default.
• W1569792304 date "2000-12-01" @default.
• W1569792304 modified "2023-09-29" @default.
• W1569792304 title "Telomerase activity in soft-tissue and bone sarcomas." @default.
• W1569792304 cites W14665893 @default.
• W1569792304 cites W1497143641 @default.
• W1569792304 cites W1500427884 @default.
• W1569792304 cites W1516734969 @default.
• W1569792304 cites W1858648870 @default.
• W1569792304 cites W1941444679 @default.
• W1569792304 cites W1943654383 @default.
• W1569792304 cites W1971838123 @default.
• W1569792304 cites W1983147046 @default.
• W1569792304 cites W1983206829 @default.
• W1569792304 cites W1992274357 @default.
• W1569792304 cites W2000971601 @default.
• W1569792304 cites W2021048030 @default.
• W1569792304 cites W2023707504 @default.
• W1569792304 cites W2028515741 @default.
• W1569792304 cites W2030976397 @default.
• W1569792304 cites W2055225985 @default.
• W1569792304 cites W2062086731 @default.
• W1569792304 cites W2062395030 @default.
• W1569792304 cites W2073743318 @default.
• W1569792304 cites W2081327669 @default.
• W1569792304 cites W2083741208 @default.
• W1569792304 cites W2090083872 @default.
• W1569792304 cites W2091151265 @default.
• W1569792304 cites W2091399755 @default.
• W1569792304 cites W2120019164 @default.
• W1569792304 cites W2126650918 @default.
• W1569792304 cites W2129940723 @default.
• W1569792304 cites W2140981145 @default.
• W1569792304 cites W2141465465 @default.
• W1569792304 cites W2148805136 @default.
• W1569792304 cites W2169455407 @default.
• W1569792304 cites W2169600394 @default.
• W1569792304 cites W2315644261 @default.
• W1569792304 cites W2333761640 @default.
• W1569792304 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11156234" @default.
• W1569792304 hasPublicationYear "2000" @default.
• W1569792304 type Work @default.
• W1569792304 sameAs 1569792304 @default.
• W1569792304 citedByCount "11" @default.
• W1569792304 countsByYear W15697923042017 @default.
• W1569792304 countsByYear W15697923042020 @default.
• W1569792304 countsByYear W15697923042023 @default.
• W1569792304 crossrefType "journal-article" @default.
• W1569792304 hasAuthorship W1569792304A5013769942 @default.
• W1569792304 hasAuthorship W1569792304A5029365885 @default.
• W1569792304 hasAuthorship W1569792304A5040297156 @default.
• W1569792304 hasAuthorship W1569792304A5040870373 @default.
• W1569792304 hasAuthorship W1569792304A5056801490 @default.
• W1569792304 hasAuthorship W1569792304A5081166185 @default.
• W1569792304 hasConcept C104317684 @default.
• W1569792304 hasConcept C121608353 @default.
• W1569792304 hasConcept C142724271 @default.
• W1569792304 hasConcept C198826908 @default.
• W1569792304 hasConcept C2775934546 @default.
• W1569792304 hasConcept C2777546739 @default.
• W1569792304 hasConcept C2778256501 @default.
• W1569792304 hasConcept C2779399171 @default.
• W1569792304 hasConcept C518705261 @default.
• W1569792304 hasConcept C54355233 @default.
• W1569792304 hasConcept C55493867 @default.
• W1569792304 hasConcept C71924100 @default.
• W1569792304 hasConcept C86803240 @default.
• W1569792304 hasConcept C94581717 @default.
• W1569792304 hasConceptScore W1569792304C104317684 @default.
• W1569792304 hasConceptScore W1569792304C121608353 @default.
• W1569792304 hasConceptScore W1569792304C142724271 @default.
• W1569792304 hasConceptScore W1569792304C198826908 @default.
• W1569792304 hasConceptScore W1569792304C2775934546 @default.
• W1569792304 hasConceptScore W1569792304C2777546739 @default.
• W1569792304 hasConceptScore W1569792304C2778256501 @default.
• W1569792304 hasConceptScore W1569792304C2779399171 @default.
• W1569792304 hasConceptScore W1569792304C518705261 @default.
• W1569792304 hasConceptScore W1569792304C54355233 @default.
• W1569792304 hasConceptScore W1569792304C55493867 @default.
• W1569792304 hasConceptScore W1569792304C71924100 @default.
• W1569792304 hasConceptScore W1569792304C86803240 @default.
• W1569792304 hasConceptScore W1569792304C94581717 @default.
• W1569792304 hasIssue "12" @default.
• W1569792304 hasLocation W15697923041 @default.
• W1569792304 hasOpenAccess W1569792304 @default.
• W1569792304 hasPrimaryLocation W15697923041 @default.
• W1569792304 hasRelatedWork W2064398663 @default.
• W1569792304 hasRelatedWork W2064687368 @default.
• W1569792304 hasRelatedWork W2098584560 @default.
• W1569792304 hasRelatedWork W2137509442 @default.
• W1569792304 hasRelatedWork W2165919621 @default.

• next