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• W1569794014 abstract "Assembly of soluble microtubule-associated protein tau into insoluble amyloid-like filaments is characteristic of many human neurodegenerative diseases, often referred to as tauopathies. They include Alzheimer's disease, Pick's disease, progressive supranuclear palsy, corticobasal degeneration and argyrophilic grain disease. The identification of dominantly inherited forms of dementia and parkinsonism that are caused by mutations in Tau has established a central role for the pathological pathway leading from soluble to filamentous tau. Although abnormal hyperphosphorylation is an invariant feature of tau assemblies, the morphologies and biochemical composition of tau filaments vary between diseases, as do the affected cell types. A gain of toxic function mechanism appears to underlie the human tauopathies." @default.
• W1569794014 created "2016-06-24" @default.
• W1569794014 creator A5037379608 @default.
• W1569794014 date "2011-09-02" @default.
• W1569794014 modified "2023-09-25" @default.
• W1569794014 title "Introduction to the Tauopathies" @default.
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• W1569794014 doi "https://doi.org/10.1002/9781444341256.ch13" @default.
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