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- W1569798034 abstract "The binding of indomethacin to human serum albumin (HSA)§ has been studied with HSA immobilized in microparticles of polyacrylamide, by equilibrim dialysis and by circular dichroism. Indomethacin is bound to three sites with high affinity. The association constants are 1.5–2.1 × 106, 3.5 × 105 and 5.5 × 104M−1, respectively, as found by spectropolarimetric titration and from Scatchard plots of data obtained from the studies with microparticles. The evaluation of the CD-data is simplified by the different extrinsic Cotton effects engendered when indomethacin binds to the different sites. With specific probes, binding exclusively to single sites, we have shown that indomethacin primarily binds to the warfarin-(azapropazone-) site and tertiarily to the diazepam-(flurbiprofen-) site on HSA. The identity of the secondary site has not been established. Probenecid does not affect the first site of indomethacin, but improves the binding of indomethacin to the second site, probably via allosteric effects from the third site." @default.
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- W1569798034 date "1980-06-01" @default.
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- W1569798034 title "Binding of drugs to human serum albumin—XV" @default.
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- W1569798034 doi "https://doi.org/10.1016/0006-2952(80)90137-9" @default.
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