Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569802940> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W1569802940 endingPage "JCD.S3660" @default.
- W1569802940 startingPage "JCD.S3660" @default.
- W1569802940 abstract "The study of death receptor family induced apoptosis has gained momentum in recent years with the knowledge that therapeutic antibodies targeting DR4 and DR5 (death receptor's 4 and 5) have proved efficacious in multiple clinical trials. The therapeutic rationale is based on targeting and amplifying a tumour tissues normal cell death programme (apoptosis). While advances in the targeting of DR4 and DR5 have been successful the search for an agonistic antibody to another family member, the Fas receptor, has proven more elusive. This is partly due to the differing in vitro and in vivo characteristics of individual antibodies. In order to induce Fas targeted cell death an antibody must be capable of binding to and trimerising the receptor. It has been shown that antibodies capable of performing this function in vivo, with the assistance of tumour associated cells, do not always induce apoptosis in vitro. As a result the use of current methodologies to detect functional antibodies in vitro may have dismissed potential therapeutic candidates ('false negative'). Here we report a novel high throughput screening technique which artificially cross-links antibodies bound to the Fas receptor. By combining this process with Annexin-V and Prodidium Iodide (PI) staining we can select for antibodies which have the potential to induce apoptosis in vivo." @default.
- W1569802940 created "2016-06-24" @default.
- W1569802940 creator A5005209374 @default.
- W1569802940 creator A5030923084 @default.
- W1569802940 creator A5036176344 @default.
- W1569802940 creator A5042449765 @default.
- W1569802940 creator A5056801628 @default.
- W1569802940 date "2009-01-01" @default.
- W1569802940 modified "2023-10-16" @default.
- W1569802940 title "A Novel High-Throughput Technique for Identifying Monoclonal Antibodies capable of Death Receptor Induced Apoptosis" @default.
- W1569802940 cites W1642763135 @default.
- W1569802940 cites W1986308149 @default.
- W1569802940 cites W2012173926 @default.
- W1569802940 cites W2021486132 @default.
- W1569802940 cites W2022123302 @default.
- W1569802940 cites W2026057304 @default.
- W1569802940 cites W2030892254 @default.
- W1569802940 cites W2034530348 @default.
- W1569802940 cites W2042647861 @default.
- W1569802940 cites W2080613199 @default.
- W1569802940 cites W2098715950 @default.
- W1569802940 cites W2141129148 @default.
- W1569802940 cites W2147084916 @default.
- W1569802940 cites W2156179144 @default.
- W1569802940 cites W2165436746 @default.
- W1569802940 doi "https://doi.org/10.4137/jcd.s3660" @default.
- W1569802940 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4474333" @default.
- W1569802940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26124680" @default.
- W1569802940 hasPublicationYear "2009" @default.
- W1569802940 type Work @default.
- W1569802940 sameAs 1569802940 @default.
- W1569802940 citedByCount "0" @default.
- W1569802940 crossrefType "journal-article" @default.
- W1569802940 hasAuthorship W1569802940A5005209374 @default.
- W1569802940 hasAuthorship W1569802940A5030923084 @default.
- W1569802940 hasAuthorship W1569802940A5036176344 @default.
- W1569802940 hasAuthorship W1569802940A5042449765 @default.
- W1569802940 hasAuthorship W1569802940A5056801628 @default.
- W1569802940 hasBestOaLocation W15698029401 @default.
- W1569802940 hasConcept C150903083 @default.
- W1569802940 hasConcept C159654299 @default.
- W1569802940 hasConcept C170493617 @default.
- W1569802940 hasConcept C190283241 @default.
- W1569802940 hasConcept C202751555 @default.
- W1569802940 hasConcept C203014093 @default.
- W1569802940 hasConcept C207001950 @default.
- W1569802940 hasConcept C2780670749 @default.
- W1569802940 hasConcept C3031857 @default.
- W1569802940 hasConcept C31573885 @default.
- W1569802940 hasConcept C502942594 @default.
- W1569802940 hasConcept C542903549 @default.
- W1569802940 hasConcept C55493867 @default.
- W1569802940 hasConcept C86803240 @default.
- W1569802940 hasConcept C88634738 @default.
- W1569802940 hasConcept C95444343 @default.
- W1569802940 hasConceptScore W1569802940C150903083 @default.
- W1569802940 hasConceptScore W1569802940C159654299 @default.
- W1569802940 hasConceptScore W1569802940C170493617 @default.
- W1569802940 hasConceptScore W1569802940C190283241 @default.
- W1569802940 hasConceptScore W1569802940C202751555 @default.
- W1569802940 hasConceptScore W1569802940C203014093 @default.
- W1569802940 hasConceptScore W1569802940C207001950 @default.
- W1569802940 hasConceptScore W1569802940C2780670749 @default.
- W1569802940 hasConceptScore W1569802940C3031857 @default.
- W1569802940 hasConceptScore W1569802940C31573885 @default.
- W1569802940 hasConceptScore W1569802940C502942594 @default.
- W1569802940 hasConceptScore W1569802940C542903549 @default.
- W1569802940 hasConceptScore W1569802940C55493867 @default.
- W1569802940 hasConceptScore W1569802940C86803240 @default.
- W1569802940 hasConceptScore W1569802940C88634738 @default.
- W1569802940 hasConceptScore W1569802940C95444343 @default.
- W1569802940 hasLocation W15698029401 @default.
- W1569802940 hasLocation W15698029402 @default.
- W1569802940 hasLocation W15698029403 @default.
- W1569802940 hasLocation W15698029404 @default.
- W1569802940 hasOpenAccess W1569802940 @default.
- W1569802940 hasPrimaryLocation W15698029401 @default.
- W1569802940 hasRelatedWork W2044152887 @default.
- W1569802940 hasRelatedWork W2044409506 @default.
- W1569802940 hasRelatedWork W2094270522 @default.
- W1569802940 hasRelatedWork W2160754355 @default.
- W1569802940 hasRelatedWork W2328739198 @default.
- W1569802940 hasRelatedWork W2337146067 @default.
- W1569802940 hasRelatedWork W2340257449 @default.
- W1569802940 hasRelatedWork W4200546529 @default.
- W1569802940 hasRelatedWork W4283693058 @default.
- W1569802940 hasRelatedWork W56025907 @default.
- W1569802940 hasVolume "2" @default.
- W1569802940 isParatext "false" @default.
- W1569802940 isRetracted "false" @default.
- W1569802940 magId "1569802940" @default.
- W1569802940 workType "article" @default.