Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569807988> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1569807988 endingPage "2529" @default.
- W1569807988 startingPage "2522" @default.
- W1569807988 abstract "It has been reported that Wnt/β-catenin signalling pathway played a key role in liver fibrosis and that Pygo2 was an important mediator in β-catenin induced pathway. However, the role of Pygo2 in liver fibrogenesis was unknown. Our study was to investigate the expression of Pygo2 and its diagnostic value in patients with HBV-related liver fibrosis.Hundred and sixty-four patients with HBV infection underwent liver biopsy and liver stiffness measurement (LSM) by transient elastography (Fibroscan(®) ; Echosens). Liver function was tested by routine biochemical examinations. Liver condition was assessed by haematoxylin and eosin (H&E) and Masson's trichrome staining. The expression of Pygo2 in liver tissue was measured by Real-time PCR and immunohistochemistry, respectively, while the serum levels of Pygo2 were detected by ELISA. The relationship between degree of liver fibrosis and Pygo2 expression was assessed by correlation analysis. Receiver operating characteristics (ROC) analysis was used to evaluate diagnostic accuracy of serum Pygo2, LSM and their combination.The mRNA and protein levels of Pygo2 in HBV-infected patients were all higher than in normal persons (P < 0.05 respectively). Moreover, Pygo2 expression increased along with the progression of liver fibrosis (P < 0.05 respectively). The trend of serum Pygo2 agreed with its expression in liver tissue. The combination of serum Pygo2 and LSM had a significantly higher area under the curve than Pygo2 or LSM alone (P < 0.05 respectively).This study suggested that Pygo2 was involved in HBV-induced liver fibrogenesis. Pygo2 is a valuable biomarker for the evaluation of fibrosis in HBV-infected patients." @default.
- W1569807988 created "2016-06-24" @default.
- W1569807988 creator A5051707259 @default.
- W1569807988 creator A5052267876 @default.
- W1569807988 creator A5076256227 @default.
- W1569807988 creator A5086471615 @default.
- W1569807988 creator A5090474210 @default.
- W1569807988 date "2015-06-22" @default.
- W1569807988 modified "2023-09-30" @default.
- W1569807988 title "Increased Pygo2 expression in liver of patients with hepatitis B virus-related fibrosis" @default.
- W1569807988 cites W1481729629 @default.
- W1569807988 cites W1844319713 @default.
- W1569807988 cites W1988986320 @default.
- W1569807988 cites W1994494617 @default.
- W1569807988 cites W2002163127 @default.
- W1569807988 cites W2004849032 @default.
- W1569807988 cites W2008202801 @default.
- W1569807988 cites W2011917285 @default.
- W1569807988 cites W2013085780 @default.
- W1569807988 cites W2021483451 @default.
- W1569807988 cites W2031317669 @default.
- W1569807988 cites W2032817476 @default.
- W1569807988 cites W2057320475 @default.
- W1569807988 cites W2077049646 @default.
- W1569807988 cites W2079482380 @default.
- W1569807988 cites W2082032249 @default.
- W1569807988 cites W2088327211 @default.
- W1569807988 cites W2094174828 @default.
- W1569807988 cites W2094639617 @default.
- W1569807988 cites W2133960281 @default.
- W1569807988 cites W2165812775 @default.
- W1569807988 cites W4247258598 @default.
- W1569807988 doi "https://doi.org/10.1111/liv.12877" @default.
- W1569807988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26013055" @default.
- W1569807988 hasPublicationYear "2015" @default.
- W1569807988 type Work @default.
- W1569807988 sameAs 1569807988 @default.
- W1569807988 citedByCount "3" @default.
- W1569807988 countsByYear W15698079882016 @default.
- W1569807988 countsByYear W15698079882018 @default.
- W1569807988 countsByYear W15698079882022 @default.
- W1569807988 crossrefType "journal-article" @default.
- W1569807988 hasAuthorship W1569807988A5051707259 @default.
- W1569807988 hasAuthorship W1569807988A5052267876 @default.
- W1569807988 hasAuthorship W1569807988A5076256227 @default.
- W1569807988 hasAuthorship W1569807988A5086471615 @default.
- W1569807988 hasAuthorship W1569807988A5090474210 @default.
- W1569807988 hasConcept C126322002 @default.
- W1569807988 hasConcept C142724271 @default.
- W1569807988 hasConcept C2775934546 @default.
- W1569807988 hasConcept C2777766500 @default.
- W1569807988 hasConcept C2780559512 @default.
- W1569807988 hasConcept C71924100 @default.
- W1569807988 hasConceptScore W1569807988C126322002 @default.
- W1569807988 hasConceptScore W1569807988C142724271 @default.
- W1569807988 hasConceptScore W1569807988C2775934546 @default.
- W1569807988 hasConceptScore W1569807988C2777766500 @default.
- W1569807988 hasConceptScore W1569807988C2780559512 @default.
- W1569807988 hasConceptScore W1569807988C71924100 @default.
- W1569807988 hasFunder F4320321001 @default.
- W1569807988 hasFunder F4320334897 @default.
- W1569807988 hasIssue "12" @default.
- W1569807988 hasLocation W15698079881 @default.
- W1569807988 hasLocation W15698079882 @default.
- W1569807988 hasOpenAccess W1569807988 @default.
- W1569807988 hasPrimaryLocation W15698079881 @default.
- W1569807988 hasRelatedWork W1998250739 @default.
- W1569807988 hasRelatedWork W2021094999 @default.
- W1569807988 hasRelatedWork W2044930714 @default.
- W1569807988 hasRelatedWork W2084320631 @default.
- W1569807988 hasRelatedWork W2258515303 @default.
- W1569807988 hasRelatedWork W2373397919 @default.
- W1569807988 hasRelatedWork W2399881402 @default.
- W1569807988 hasRelatedWork W2405975318 @default.
- W1569807988 hasRelatedWork W2765384989 @default.
- W1569807988 hasRelatedWork W3180662970 @default.
- W1569807988 hasVolume "35" @default.
- W1569807988 isParatext "false" @default.
- W1569807988 isRetracted "false" @default.
- W1569807988 magId "1569807988" @default.
- W1569807988 workType "article" @default.