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- W1569809796 abstract "Models are increasingly being used to address a wide range of issues in public health and disease control, and combined with economic analyses, to provide insights into the optimal design of mass vaccination programs. Models are also useful to inform vaccine trial design and analysis to help identify promising vaccine candidates. Simulating trials before implementation is a very valuable tool to maximize the likelihood of identifying the true efficacy of a candidate under field trial conditions. In this chapter, we summarize key principles governing the impact of vaccines on infectious disease transmission and discuss how an understanding of these principles can be used to optimize the design of mass or targeted vaccination programmes. We also discuss how economic factors can be incorporated into mathematical models of infectious agent transmission and intervention impact. Finally, we also introduce the more novel use of mathematical models at different stage of vaccine development and efficacy assessment." @default.
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- W1569809796 date "2012-06-20" @default.
- W1569809796 modified "2023-10-05" @default.
- W1569809796 title "The Role of Mathematical Models in Vaccine Development and Public Health Decision Making" @default.
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- W1569809796 doi "https://doi.org/10.1002/9781118345313.ch32" @default.
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