FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569809977> ?p ?o ?g. }

• W1569809977 endingPage "21" @default.
• W1569809977 startingPage "2412" @default.
• W1569809977 abstract "To ascribe activating transcription factor (ATF)-3 as a specifically induced transcription factor after ON injury and to describe its putative role as a modulator of c-Jun transactivation.The adult rat optic nerve was crushed intraorbitally, and expression profiles of ATF-3, ATF-2, and phosphorylated c-Jun (p-c-Jun) were examined by immunohistochemistry and ISH. Western blot analysis for ATF-3 and -2 were also performed. Furthermore, colocalized detection of c-Jun mRNA with ATF-2 or -3 was attempted with a combined method of simultaneous immunohistochemistry and in situ hybridization.In response to optic nerve injury, substantial expression of ATF-3 as well as that of p-c-Jun was observed in the retinal ganglion cells, whereas no expression of ATF-3 was seen in other noninjured retinal cells. In contrast, ATF-2 was normally expressed abundantly in both retinal ganglion cells and displaced amacrine cells, but expression dropped in retinal ganglion cells after nerve injury. The expression profiles of ATF-2 and -3 after optic nerve injury were confirmed by Western blot analysis. A higher degree of colocalization was observed for ATF-3 and c-Jun than the modest codetection for ATF-2 and c-Jun.The transcription factor ATF-3 is specifically induced upon optic nerve injury and colocalizes with p-c-Jun in surviving ganglion cells. These findings suggest that both ATF-3 and c-Jun are crucial to trigger various transcriptional responses and may act synergistically during the survival phase of the optic nerve in the injury model." @default.
• W1569809977 created "2016-06-24" @default.
• W1569809977 creator A5001558889 @default.
• W1569809977 creator A5009299506 @default.
• W1569809977 creator A5061446233 @default.
• W1569809977 creator A5072006202 @default.
• W1569809977 creator A5075627852 @default.
• W1569809977 date "2000-08-01" @default.
• W1569809977 modified "2023-10-16" @default.
• W1569809977 title "Injury-specific expression of activating transcription factor-3 in retinal ganglion cells and its colocalized expression with phosphorylated c-Jun." @default.
• W1569809977 cites W1491979926 @default.
• W1569809977 cites W1493533123 @default.
• W1569809977 cites W1502563373 @default.
• W1569809977 cites W1502827848 @default.
• W1569809977 cites W1549081254 @default.
• W1569809977 cites W1561961789 @default.
• W1569809977 cites W1692197226 @default.
• W1569809977 cites W1869555064 @default.
• W1569809977 cites W1906407967 @default.
• W1569809977 cites W1945304257 @default.
• W1569809977 cites W1967753443 @default.
• W1569809977 cites W1968015127 @default.
• W1569809977 cites W1969281472 @default.
• W1569809977 cites W1972603245 @default.
• W1569809977 cites W1974175450 @default.
• W1569809977 cites W1977302628 @default.
• W1569809977 cites W1977661385 @default.
• W1569809977 cites W1979200545 @default.
• W1569809977 cites W1980809507 @default.
• W1569809977 cites W1981059908 @default.
• W1569809977 cites W1982114966 @default.
• W1569809977 cites W1987601714 @default.
• W1569809977 cites W2002564316 @default.
• W1569809977 cites W2007132484 @default.
• W1569809977 cites W2008715447 @default.
• W1569809977 cites W2009802452 @default.
• W1569809977 cites W2011867384 @default.
• W1569809977 cites W2028245723 @default.
• W1569809977 cites W2028894615 @default.
• W1569809977 cites W2035784540 @default.
• W1569809977 cites W2036224418 @default.
• W1569809977 cites W2042052313 @default.
• W1569809977 cites W2042260090 @default.
• W1569809977 cites W2043344536 @default.
• W1569809977 cites W2047150313 @default.
• W1569809977 cites W2051950569 @default.
• W1569809977 cites W2053208432 @default.
• W1569809977 cites W2063281599 @default.
• W1569809977 cites W2067837253 @default.
• W1569809977 cites W2068781335 @default.
• W1569809977 cites W2082060785 @default.
• W1569809977 cites W2084304228 @default.
• W1569809977 cites W2094182857 @default.
• W1569809977 cites W2098132781 @default.
• W1569809977 cites W2111679150 @default.
• W1569809977 cites W2112294647 @default.
• W1569809977 cites W2118741542 @default.
• W1569809977 cites W2118897660 @default.
• W1569809977 cites W2120955132 @default.
• W1569809977 cites W2135406143 @default.
• W1569809977 cites W2139488506 @default.
• W1569809977 cites W2153385508 @default.
• W1569809977 cites W2156172491 @default.
• W1569809977 cites W2159872853 @default.
• W1569809977 cites W2168858114 @default.
• W1569809977 cites W2406818336 @default.
• W1569809977 cites W39296774 @default.
• W1569809977 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10937548" @default.
• W1569809977 hasPublicationYear "2000" @default.
• W1569809977 type Work @default.
• W1569809977 sameAs 1569809977 @default.
• W1569809977 citedByCount "30" @default.
• W1569809977 countsByYear W15698099772012 @default.
• W1569809977 countsByYear W15698099772013 @default.
• W1569809977 countsByYear W15698099772014 @default.
• W1569809977 countsByYear W15698099772015 @default.
• W1569809977 countsByYear W15698099772017 @default.
• W1569809977 countsByYear W15698099772018 @default.
• W1569809977 countsByYear W15698099772019 @default.
• W1569809977 countsByYear W15698099772021 @default.
• W1569809977 countsByYear W15698099772022 @default.
• W1569809977 countsByYear W15698099772023 @default.
• W1569809977 crossrefType "journal-article" @default.
• W1569809977 hasAuthorship W1569809977A5001558889 @default.
• W1569809977 hasAuthorship W1569809977A5009299506 @default.
• W1569809977 hasAuthorship W1569809977A5061446233 @default.
• W1569809977 hasAuthorship W1569809977A5072006202 @default.
• W1569809977 hasAuthorship W1569809977A5075627852 @default.
• W1569809977 hasConcept C104317684 @default.
• W1569809977 hasConcept C105702510 @default.
• W1569809977 hasConcept C1292079 @default.
• W1569809977 hasConcept C153911025 @default.
• W1569809977 hasConcept C169760540 @default.
• W1569809977 hasConcept C2776415932 @default.
• W1569809977 hasConcept C2777093970 @default.
• W1569809977 hasConcept C2777624874 @default.
• W1569809977 hasConcept C2779087070 @default.
• W1569809977 hasConcept C2780188069 @default.

• next