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- W1569840127 abstract "Interleukin-31 (IL-31), a recently discovered cytokine derived from T helper cells, is involved in chronic dermatitis and pruritus. This study demonstrates for the first time that the IL-31 receptor complex for IL-31 is substantially upregulated in human dermal microvascular endothelial cells after stimulation with interferon-γ (IFN-γ). Activation of the IL-31 receptor complex results in the induction of the intracellular ERK1/2 signaling pathway and downregulation of IFN-γ-induced monokine induced by IFN-γ expression. Inhibitor studies revealed that the IFN-γ-induced IL-31RA upregulation is processed via JNK and PI3 kinase activation. In sum, our study points toward an interaction between the T(H) 1-derived cytokine IFN-γ and the T(H) 2-derived cytokine IL-31 on endothelial cells." @default.
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- W1569840127 date "2010-09-17" @default.
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- W1569840127 title "Interferon-γ induces upregulation and activation of the interleukin-31 receptor in human dermal microvascular endothelial cells" @default.
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- W1569840127 doi "https://doi.org/10.1111/j.1600-0625.2010.01147.x" @default.
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