FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569843392> ?p ?o ?g. }

• W1569843392 endingPage "144" @default.
• W1569843392 startingPage "140" @default.
• W1569843392 abstract "Objective:To evaluate the role of proteasome inhibitor MG-132 in reversing the acquired TRAIL resistance of human colon cancer cell line DLD1-TRAIL/R and the related mechanisms.Methods:Colon cancer cell line DLD1-TRAIL/R was treated with MG-132 combined with TRAIL protein.The viability of DLD1-TRAIL/R cells was determined by MTT assay;the apoptotic rate was detected by flow cytometry,and the expression of apoptosis-related proteins was examined by Western blotting analysis.Results:The viability of DLD1-TRAIL/R cells was dramatically decreased after combined treatment with MG-132 and TRAIL protein(P0.01) and the apoptotic rate was significantly increased(P0.01).Western blotting analysis showed that MG-132 dramatically enhanced the cleavage of apoptotic molecules,including caspases-8,9,3,Bid,and PARP in DLD1-TRAIL/R cells after combined treatment and increased the release of cytochrome C and Smac from mitochondria.Further study demonstrated that MG-132 up-regulated DR5 and Bik proteins,but had no detectable effects on DR4,Bax,Bak,Bcl-XL,XIAP or survivin.Moreover,we found MG-132 induced phosphorylation of kinase JNK,and the inhibitor of JNK(SP600125) blocked MG-132-induced expression of DR5,but not the expression of Bik.Furthermore,SP600125 did not attenuate the apoptosis of DLD1-TRAIL/R cells induced by MG132 in the presence of TRAIL protein(P0.05).Conclusion:Proteasome inhibitor MG-132 can reverse the acquired drug resistance to TRAIL and induce up-regulation of DR5 and Bik protein in DLD1-TRAIL/R cells.The underlying mechanism may involve the initiation of mitochondrion-related apoptosis caused by Bik protein expression,not by activation of JNK pathway." @default.
• W1569843392 created "2016-06-24" @default.
• W1569843392 creator A5008498701 @default.
• W1569843392 creator A5039243401 @default.
• W1569843392 creator A5045856174 @default.
• W1569843392 creator A5080524557 @default.
• W1569843392 creator A5081884581 @default.
• W1569843392 date "2009-01-01" @default.
• W1569843392 modified "2023-09-26" @default.
• W1569843392 title "Proteasome inhibitor MG-132 reverses acquired resistance to TRAIL in human colon cancer cells." @default.
• W1569843392 hasPublicationYear "2009" @default.
• W1569843392 type Work @default.
• W1569843392 sameAs 1569843392 @default.
• W1569843392 citedByCount "0" @default.
• W1569843392 crossrefType "journal-article" @default.
• W1569843392 hasAuthorship W1569843392A5008498701 @default.
• W1569843392 hasAuthorship W1569843392A5039243401 @default.
• W1569843392 hasAuthorship W1569843392A5045856174 @default.
• W1569843392 hasAuthorship W1569843392A5080524557 @default.
• W1569843392 hasAuthorship W1569843392A5081884581 @default.
• W1569843392 hasConcept C104317684 @default.
• W1569843392 hasConcept C11960822 @default.
• W1569843392 hasConcept C121608353 @default.
• W1569843392 hasConcept C126322002 @default.
• W1569843392 hasConcept C1491633281 @default.
• W1569843392 hasConcept C153911025 @default.
• W1569843392 hasConcept C185592680 @default.
• W1569843392 hasConcept C190283241 @default.
• W1569843392 hasConcept C2775975398 @default.
• W1569843392 hasConcept C2777366897 @default.
• W1569843392 hasConcept C2777408456 @default.
• W1569843392 hasConcept C2777730290 @default.
• W1569843392 hasConcept C2778367456 @default.
• W1569843392 hasConcept C2778506107 @default.
• W1569843392 hasConcept C2779730028 @default.
• W1569843392 hasConcept C2780783641 @default.
• W1569843392 hasConcept C31573885 @default.
• W1569843392 hasConcept C33195913 @default.
• W1569843392 hasConcept C53227056 @default.
• W1569843392 hasConcept C54355233 @default.
• W1569843392 hasConcept C553184892 @default.
• W1569843392 hasConcept C55493867 @default.
• W1569843392 hasConcept C71924100 @default.
• W1569843392 hasConcept C81885089 @default.
• W1569843392 hasConcept C85265743 @default.
• W1569843392 hasConcept C86803240 @default.
• W1569843392 hasConcept C96232424 @default.
• W1569843392 hasConcept C98424977 @default.
• W1569843392 hasConceptScore W1569843392C104317684 @default.
• W1569843392 hasConceptScore W1569843392C11960822 @default.
• W1569843392 hasConceptScore W1569843392C121608353 @default.
• W1569843392 hasConceptScore W1569843392C126322002 @default.
• W1569843392 hasConceptScore W1569843392C1491633281 @default.
• W1569843392 hasConceptScore W1569843392C153911025 @default.
• W1569843392 hasConceptScore W1569843392C185592680 @default.
• W1569843392 hasConceptScore W1569843392C190283241 @default.
• W1569843392 hasConceptScore W1569843392C2775975398 @default.
• W1569843392 hasConceptScore W1569843392C2777366897 @default.
• W1569843392 hasConceptScore W1569843392C2777408456 @default.
• W1569843392 hasConceptScore W1569843392C2777730290 @default.
• W1569843392 hasConceptScore W1569843392C2778367456 @default.
• W1569843392 hasConceptScore W1569843392C2778506107 @default.
• W1569843392 hasConceptScore W1569843392C2779730028 @default.
• W1569843392 hasConceptScore W1569843392C2780783641 @default.
• W1569843392 hasConceptScore W1569843392C31573885 @default.
• W1569843392 hasConceptScore W1569843392C33195913 @default.
• W1569843392 hasConceptScore W1569843392C53227056 @default.
• W1569843392 hasConceptScore W1569843392C54355233 @default.
• W1569843392 hasConceptScore W1569843392C553184892 @default.
• W1569843392 hasConceptScore W1569843392C55493867 @default.
• W1569843392 hasConceptScore W1569843392C71924100 @default.
• W1569843392 hasConceptScore W1569843392C81885089 @default.
• W1569843392 hasConceptScore W1569843392C85265743 @default.
• W1569843392 hasConceptScore W1569843392C86803240 @default.
• W1569843392 hasConceptScore W1569843392C96232424 @default.
• W1569843392 hasConceptScore W1569843392C98424977 @default.
• W1569843392 hasIssue "2" @default.
• W1569843392 hasLocation W15698433921 @default.
• W1569843392 hasOpenAccess W1569843392 @default.
• W1569843392 hasPrimaryLocation W15698433921 @default.
• W1569843392 hasRelatedWork W1578297055 @default.
• W1569843392 hasRelatedWork W2004601948 @default.
• W1569843392 hasRelatedWork W2062938379 @default.
• W1569843392 hasRelatedWork W2075944299 @default.
• W1569843392 hasRelatedWork W2306451269 @default.
• W1569843392 hasRelatedWork W2348453173 @default.
• W1569843392 hasRelatedWork W2366877613 @default.
• W1569843392 hasRelatedWork W2409693524 @default.
• W1569843392 hasRelatedWork W2553456500 @default.
• W1569843392 hasRelatedWork W2566546830 @default.
• W1569843392 hasRelatedWork W2569775949 @default.
• W1569843392 hasRelatedWork W2763239300 @default.
• W1569843392 hasRelatedWork W2810524345 @default.
• W1569843392 hasRelatedWork W3030785224 @default.
• W1569843392 hasRelatedWork W3032759090 @default.
• W1569843392 hasRelatedWork W3035733148 @default.
• W1569843392 hasRelatedWork W3046204606 @default.
• W1569843392 hasRelatedWork W3121430274 @default.

• next