FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569846874> ?p ?o ?g. }

• W1569846874 endingPage "e0130955" @default.
• W1569846874 startingPage "e0130955" @default.
• W1569846874 abstract "Staphylococcus aureus is an important clinical pathogen worldwide and understanding this organism's phylogeny and, in particular, the role of recombination, is important both to understand the overall spread of virulent lineages and to characterize outbreaks. To further elucidate the phylogeny of S. aureus, 35 diverse strains were sequenced using whole genome sequencing. In addition, 29 publicly available whole genome sequences were included to create a single nucleotide polymorphism (SNP)-based phylogenetic tree encompassing 11 distinct lineages. All strains of a particular sequence type fell into the same clade with clear groupings of the major clonal complexes of CC8, CC5, CC30, CC45 and CC1. Using a novel analysis method, we plotted the homoplasy density and SNP density across the whole genome and found evidence of recombination throughout the entire chromosome, but when we examined individual clonal lineages we found very little recombination. However, when we analyzed three branches of multiple lineages, we saw intermediate and differing levels of recombination between them. These data demonstrate that in S. aureus, recombination occurs across major lineages that subsequently expand in a clonal manner. Estimated mutation rates for the CC8 and CC5 lineages were different from each other. While the CC8 lineage rate was similar to previous studies, the CC5 lineage was 100-fold greater. Fifty known virulence genes were screened in all genomes in silico to determine their distribution across major clades. Thirty-three genes were present variably across clades, most of which were not constrained by ancestry, indicating horizontal gene transfer or gene loss." @default.
• W1569846874 created "2016-06-24" @default.
• W1569846874 creator A5007455008 @default.
• W1569846874 creator A5019273406 @default.
• W1569846874 creator A5020521991 @default.
• W1569846874 creator A5025613930 @default.
• W1569846874 creator A5030762180 @default.
• W1569846874 creator A5036350640 @default.
• W1569846874 creator A5045601734 @default.
• W1569846874 creator A5054386384 @default.
• W1569846874 creator A5055124197 @default.
• W1569846874 creator A5057905239 @default.
• W1569846874 creator A5062294709 @default.
• W1569846874 creator A5062721329 @default.
• W1569846874 creator A5070581600 @default.
• W1569846874 creator A5072982028 @default.
• W1569846874 creator A5074325811 @default.
• W1569846874 creator A5081346172 @default.
• W1569846874 creator A5086966607 @default.
• W1569846874 date "2015-07-10" @default.
• W1569846874 modified "2023-10-14" @default.
• W1569846874 title "Using Whole Genome Analysis to Examine Recombination across Diverse Sequence Types of Staphylococcus aureus" @default.
• W1569846874 cites W1516095885 @default.
• W1569846874 cites W1529607257 @default.
• W1569846874 cites W1832474629 @default.
• W1569846874 cites W1980030331 @default.
• W1569846874 cites W1984141040 @default.
• W1569846874 cites W1984791245 @default.
• W1569846874 cites W1988722434 @default.
• W1569846874 cites W1990679118 @default.
• W1569846874 cites W2000240444 @default.
• W1569846874 cites W2002457905 @default.
• W1569846874 cites W2005522415 @default.
• W1569846874 cites W2005636153 @default.
• W1569846874 cites W2009596137 @default.
• W1569846874 cites W2013164703 @default.
• W1569846874 cites W2014356675 @default.
• W1569846874 cites W2018895173 @default.
• W1569846874 cites W2019105001 @default.
• W1569846874 cites W2028031087 @default.
• W1569846874 cites W2029893213 @default.
• W1569846874 cites W2037113830 @default.
• W1569846874 cites W2039721978 @default.
• W1569846874 cites W2043901880 @default.
• W1569846874 cites W2053344896 @default.
• W1569846874 cites W2054504313 @default.
• W1569846874 cites W2074833109 @default.
• W1569846874 cites W2088701712 @default.
• W1569846874 cites W2091828194 @default.
• W1569846874 cites W2094217997 @default.
• W1569846874 cites W2094939159 @default.
• W1569846874 cites W2098998255 @default.
• W1569846874 cites W2104416613 @default.
• W1569846874 cites W2107282968 @default.
• W1569846874 cites W2108223609 @default.
• W1569846874 cites W2108344826 @default.
• W1569846874 cites W2110459646 @default.
• W1569846874 cites W2110695024 @default.
• W1569846874 cites W2115127793 @default.
• W1569846874 cites W2117317974 @default.
• W1569846874 cites W2117686662 @default.
• W1569846874 cites W2118048521 @default.
• W1569846874 cites W2120622846 @default.
• W1569846874 cites W2124717759 @default.
• W1569846874 cites W2125121305 @default.
• W1569846874 cites W2129202443 @default.
• W1569846874 cites W2130362098 @default.
• W1569846874 cites W2130920842 @default.
• W1569846874 cites W2132632499 @default.
• W1569846874 cites W2133971211 @default.
• W1569846874 cites W2134529369 @default.
• W1569846874 cites W2134937983 @default.
• W1569846874 cites W2138738218 @default.
• W1569846874 cites W2142813640 @default.
• W1569846874 cites W2144941245 @default.
• W1569846874 cites W2144975624 @default.
• W1569846874 cites W2145240901 @default.
• W1569846874 cites W2149567036 @default.
• W1569846874 cites W2150427457 @default.
• W1569846874 cites W2151150074 @default.
• W1569846874 cites W2151176484 @default.
• W1569846874 cites W2158685996 @default.
• W1569846874 cites W2158714788 @default.
• W1569846874 cites W2158804744 @default.
• W1569846874 cites W2160969485 @default.
• W1569846874 cites W2168482920 @default.
• W1569846874 cites W2170205901 @default.
• W1569846874 cites W2170367123 @default.
• W1569846874 cites W2171142493 @default.
• W1569846874 doi "https://doi.org/10.1371/journal.pone.0130955" @default.
• W1569846874 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4498916" @default.
• W1569846874 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26161978" @default.
• W1569846874 hasPublicationYear "2015" @default.
• W1569846874 type Work @default.
• W1569846874 sameAs 1569846874 @default.
• W1569846874 citedByCount "34" @default.
• W1569846874 countsByYear W15698468742016 @default.
• W1569846874 countsByYear W15698468742017 @default.

• next