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- W1569853361 abstract "Abstract B cells are present in the thymus in numbers similar to dendritic cells and epithelial cells, but the functional roles of thymic B cells and the mechanisms that support this population are unclear. Previously, we showed B cells are essential for endogenous superantigen-mediated thymocyte negative selection. In this study, we investigated mechanisms regulating thymic B cells. Thymic B cell frequency and absolute number are markedly lower in TCRa KO mice, indicating the necessity of SP-T cells for maintenance of thymic B cells. Thymic B cell numbers are also reduced in mice expressing a TCR Tg in absence of antigenic ligand, but dramatically increased in mice expressing both TCR and corresponding ligand, demonstrating TCR recognition and thymocyte activation strongly influence thymic B cells. To elucidate molecular interactions that underlie the requirement for activated T cells, we tested the role of CD40L expressed on activated SP-T cells interacting with CD40 to mediate thymic B cell maintenance. In CD40L and CD40 KO, thymic B cell frequency is substantially reduced. In mixed BM-chimeras in which CD40 KO and WT donor-derived cells co-exist, cell autonomous CD40 expression is important for thymic B cell maintenance, whereas mixed BM-chimeras using MHCII KO and WT showed that cell autonomous MHCII expression plays no detectable role. Thus, CD40L-CD40 cognate interaction, but not MHCII-TCR cognate interaction, between T cells and B cells supports the thymic B cell population." @default.
- W1569853361 created "2016-06-24" @default.
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- W1569853361 date "2014-05-01" @default.
- W1569853361 modified "2023-09-23" @default.
- W1569853361 title "Cognate CD40-CD40L interaction is important for maintenance of thymic B cells. (IRM8P.705)" @default.
- W1569853361 doi "https://doi.org/10.4049/jimmunol.192.supp.127.6" @default.
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