FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569872235> ?p ?o ?g. }

• W1569872235 endingPage "1087" @default.
• W1569872235 startingPage "1079" @default.
• W1569872235 abstract "BACKGROUND: In thrombotic thrombocytopenic purpura (TTP), ultralarge von Willebrand factor (VWF) multimers bind platelet (PLT) glycoprotein Ib and lead to the formation of disseminated fibrin‐poor, VWF‐rich PLT thrombi. The aptamer ARC1779 blocks binding of the VWF A1 domain to PLT glycoprotein Ib. We evaluated whether ARC1779 inhibits the excessive VWF activity and VWF‐mediated PLT function in patients with TTP. STUDY DESIGN AND METHODS: We studied the ex vivo concentration response curves for ARC1779 on PLT function analyzer (PFA‐100, Dade Behring) and cone‐and‐plate analyzer (CPA, Impact‐R) PLT function tests, agonist‐induced PLT aggregation, and VWF activity of TTP patients (n = 11, three in acute phase and eight in remission) and healthy controls (n = 44). RESULTS: VWF activity and VWF‐dependent PLT plug formation were increased in TTP patients relative to healthy controls, but agonist‐induced PLT aggregation was not. ARC1779 blocked collagen/adenosine 5′‐diphosphate (ADP)‐induced PLT plug formation as measured by PFA‐100 with an inhibitory concentration (IC) 100 of approximately 1 µg/mL in citrate‐anticoagulated samples and approximately 3 to 4 µg/mL in hirudin‐anticoagulated samples. A similar concentration of ARC1779 was necessary to block shear‐dependent PLT adhesion in both TTP patients and healthy controls using the CPA assay (IC 100 of approx. 1 µg/mL for both). ARC1779 blocked VWF activity with an IC 90 of approximately 3 to 4 µg/mL in all subjects, but did not inhibit PLT aggregation by ADP, collagen, or arachidonic acid even at concentrations much greater than those that fully inhibited VWF‐dependent PLT function. CONCLUSIONS: ARC1779 potently and specifically inhibits VWF activity and VWF‐dependent PLT function. ARC1779 may be a promising novel therapeutic for the treatment of TTP." @default.
• W1569872235 created "2016-06-24" @default.
• W1569872235 creator A5019057353 @default.
• W1569872235 creator A5020230031 @default.
• W1569872235 creator A5030107346 @default.
• W1569872235 creator A5052643853 @default.
• W1569872235 creator A5059547821 @default.
• W1569872235 creator A5074348178 @default.
• W1569872235 creator A5077198726 @default.
• W1569872235 creator A5080941679 @default.
• W1569872235 date "2010-04-28" @default.
• W1569872235 modified "2023-10-16" @default.
• W1569872235 title "The aptamer ARC1779 blocks von Willebrand factor-dependent platelet function in patients with thrombotic thrombocytopenic purpura ex vivo" @default.
• W1569872235 cites W134833348 @default.
• W1569872235 cites W1964095591 @default.
• W1569872235 cites W1968931774 @default.
• W1569872235 cites W1982383022 @default.
• W1569872235 cites W1985811573 @default.
• W1569872235 cites W1987175271 @default.
• W1569872235 cites W1999035667 @default.
• W1569872235 cites W2027106701 @default.
• W1569872235 cites W2030050924 @default.
• W1569872235 cites W2031336681 @default.
• W1569872235 cites W2037689490 @default.
• W1569872235 cites W2041065426 @default.
• W1569872235 cites W2042414158 @default.
• W1569872235 cites W2047376380 @default.
• W1569872235 cites W2056238936 @default.
• W1569872235 cites W2063529127 @default.
• W1569872235 cites W2081415740 @default.
• W1569872235 cites W2082076972 @default.
• W1569872235 cites W2094859665 @default.
• W1569872235 cites W2095631860 @default.
• W1569872235 cites W2102584723 @default.
• W1569872235 cites W2105484180 @default.
• W1569872235 cites W2121910371 @default.
• W1569872235 cites W2122536819 @default.
• W1569872235 cites W2126939631 @default.
• W1569872235 cites W2140918145 @default.
• W1569872235 cites W2142296100 @default.
• W1569872235 cites W2146888047 @default.
• W1569872235 cites W2151503986 @default.
• W1569872235 cites W2155387100 @default.
• W1569872235 cites W2156735099 @default.
• W1569872235 cites W2160259573 @default.
• W1569872235 cites W2334213116 @default.
• W1569872235 cites W2792574807 @default.
• W1569872235 cites W4238378618 @default.
• W1569872235 doi "https://doi.org/10.1111/j.1537-2995.2009.02554.x" @default.
• W1569872235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20070617" @default.
• W1569872235 hasPublicationYear "2010" @default.
• W1569872235 type Work @default.
• W1569872235 sameAs 1569872235 @default.
• W1569872235 citedByCount "50" @default.
• W1569872235 countsByYear W15698722352012 @default.
• W1569872235 countsByYear W15698722352013 @default.
• W1569872235 countsByYear W15698722352014 @default.
• W1569872235 countsByYear W15698722352015 @default.
• W1569872235 countsByYear W15698722352016 @default.
• W1569872235 countsByYear W15698722352018 @default.
• W1569872235 countsByYear W15698722352019 @default.
• W1569872235 countsByYear W15698722352020 @default.
• W1569872235 countsByYear W15698722352021 @default.
• W1569872235 countsByYear W15698722352022 @default.
• W1569872235 countsByYear W15698722352023 @default.
• W1569872235 crossrefType "journal-article" @default.
• W1569872235 hasAuthorship W1569872235A5019057353 @default.
• W1569872235 hasAuthorship W1569872235A5020230031 @default.
• W1569872235 hasAuthorship W1569872235A5030107346 @default.
• W1569872235 hasAuthorship W1569872235A5052643853 @default.
• W1569872235 hasAuthorship W1569872235A5059547821 @default.
• W1569872235 hasAuthorship W1569872235A5074348178 @default.
• W1569872235 hasAuthorship W1569872235A5077198726 @default.
• W1569872235 hasAuthorship W1569872235A5080941679 @default.
• W1569872235 hasConcept C126322002 @default.
• W1569872235 hasConcept C150903083 @default.
• W1569872235 hasConcept C153911025 @default.
• W1569872235 hasConcept C185592680 @default.
• W1569872235 hasConcept C202751555 @default.
• W1569872235 hasConcept C203014093 @default.
• W1569872235 hasConcept C207001950 @default.
• W1569872235 hasConcept C26291073 @default.
• W1569872235 hasConcept C2776057759 @default.
• W1569872235 hasConcept C2777399203 @default.
• W1569872235 hasConcept C2777628954 @default.
• W1569872235 hasConcept C2777849778 @default.
• W1569872235 hasConcept C2778585876 @default.
• W1569872235 hasConcept C2778905298 @default.
• W1569872235 hasConcept C2779394231 @default.
• W1569872235 hasConcept C2780921031 @default.
• W1569872235 hasConcept C2993802102 @default.
• W1569872235 hasConcept C55493867 @default.
• W1569872235 hasConcept C71924100 @default.
• W1569872235 hasConcept C86803240 @default.
• W1569872235 hasConcept C89560881 @default.
• W1569872235 hasConceptScore W1569872235C126322002 @default.
• W1569872235 hasConceptScore W1569872235C150903083 @default.
• W1569872235 hasConceptScore W1569872235C153911025 @default.

• next