FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569876593> ?p ?o ?g. }

• W1569876593 endingPage "612" @default.
• W1569876593 startingPage "606" @default.
• W1569876593 abstract "The integration of human papillomavirus (HPV) DNA into the human genome has been generally accepted as a characteristic of malignant lesions. To gain a better understanding of this phenomenon, genomic DNA from 181 cervical biopsy specimens was isolated and analyzed for HPV type and physical state of the HPV genome. These specimens represented the full spectrum of cervical disease, from condyloma to invasive carcinoma. Discrimination between integrated and episomal HPV DNA was accomplished by the detection of HPV-human DNA junction fragments on Southern blots. In most cases in which ambiguous Southern blot results were obtained, the specimens were reanalyzed by two-dimensional gel electrophoresis. Of the 100 biopsy specimens of cervical intraepithelial neoplasia analyzed, only 3 showed integrated HPV DNA, in contrast to 56 (81%) of 69 cervical carcinomas (P less than 0.001) showing integrated HPV DNA. Of the 40 carcinomas containing HPV 16 DNA, 29 (72%) had integrated HPV DNA, of which 8 (20%) also had episomal HPV DNA. In 11 (27%) cancers, only episomal HPV 16 DNA was detected. All 23 HPV 18-containing carcinomas had integrated HPV DNA, and 1 also had episomal HPV 18 DNA. The difference between HPV types 16 and 18 with respect to frequency of integration was statistically significant (P less than 0.01). The results of this study indicate that detectable integration of HPV DNA, regardless of type, occurs infrequently in cervical intraepithelial neoplasia. The absence of HPV 16 DNA integration in some carcinomas implies that integration is not always required for malignant progression. In contrast, the consistent integration of HPV 18 DNA in all cervical cancers examined may be related to its greater transforming efficiency in vitro and its reported clinical association with more aggressive cervical cancers." @default.
• W1569876593 created "2016-06-24" @default.
• W1569876593 creator A5001646894 @default.
• W1569876593 creator A5033719178 @default.
• W1569876593 creator A5034020632 @default.
• W1569876593 creator A5046828137 @default.
• W1569876593 date "1991-02-01" @default.
• W1569876593 modified "2023-10-15" @default.
• W1569876593 title "Analysis of the physical state of different human papillomavirus DNAs in intraepithelial and invasive cervical neoplasm" @default.
• W1569876593 cites W1501498790 @default.
• W1569876593 cites W1513035815 @default.
• W1569876593 cites W1849162682 @default.
• W1569876593 cites W1913557261 @default.
• W1569876593 cites W1969353948 @default.
• W1569876593 cites W1973651350 @default.
• W1569876593 cites W1976051908 @default.
• W1569876593 cites W1997525190 @default.
• W1569876593 cites W2000756291 @default.
• W1569876593 cites W2031920668 @default.
• W1569876593 cites W2031961738 @default.
• W1569876593 cites W2033207270 @default.
• W1569876593 cites W2033882604 @default.
• W1569876593 cites W2063450941 @default.
• W1569876593 cites W2064205827 @default.
• W1569876593 cites W2066354115 @default.
• W1569876593 cites W2076028837 @default.
• W1569876593 cites W2078341711 @default.
• W1569876593 cites W2091091922 @default.
• W1569876593 cites W2145550230 @default.
• W1569876593 cites W2149315362 @default.
• W1569876593 cites W2151066134 @default.
• W1569876593 cites W2170171740 @default.
• W1569876593 cites W2276286791 @default.
• W1569876593 cites W2416799626 @default.
• W1569876593 cites W2464764930 @default.
• W1569876593 cites W79384053 @default.
• W1569876593 cites W82698608 @default.
• W1569876593 cites W1969081497 @default.
• W1569876593 doi "https://doi.org/10.1128/jvi.65.2.606-612.1991" @default.
• W1569876593 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/239798" @default.
• W1569876593 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1846186" @default.
• W1569876593 hasPublicationYear "1991" @default.
• W1569876593 type Work @default.
• W1569876593 sameAs 1569876593 @default.
• W1569876593 citedByCount "545" @default.
• W1569876593 countsByYear W15698765932012 @default.
• W1569876593 countsByYear W15698765932013 @default.
• W1569876593 countsByYear W15698765932014 @default.
• W1569876593 countsByYear W15698765932015 @default.
• W1569876593 countsByYear W15698765932016 @default.
• W1569876593 countsByYear W15698765932017 @default.
• W1569876593 countsByYear W15698765932018 @default.
• W1569876593 countsByYear W15698765932019 @default.
• W1569876593 countsByYear W15698765932020 @default.
• W1569876593 countsByYear W15698765932021 @default.
• W1569876593 countsByYear W15698765932022 @default.
• W1569876593 countsByYear W15698765932023 @default.
• W1569876593 crossrefType "journal-article" @default.
• W1569876593 hasAuthorship W1569876593A5001646894 @default.
• W1569876593 hasAuthorship W1569876593A5033719178 @default.
• W1569876593 hasAuthorship W1569876593A5034020632 @default.
• W1569876593 hasAuthorship W1569876593A5046828137 @default.
• W1569876593 hasBestOaLocation W15698765931 @default.
• W1569876593 hasConcept C121608353 @default.
• W1569876593 hasConcept C133307689 @default.
• W1569876593 hasConcept C142724271 @default.
• W1569876593 hasConcept C153911025 @default.
• W1569876593 hasConcept C159047783 @default.
• W1569876593 hasConcept C2775934546 @default.
• W1569876593 hasConcept C2776235491 @default.
• W1569876593 hasConcept C2777343196 @default.
• W1569876593 hasConcept C2778220009 @default.
• W1569876593 hasConcept C2779534503 @default.
• W1569876593 hasConcept C54355233 @default.
• W1569876593 hasConcept C552990157 @default.
• W1569876593 hasConcept C71924100 @default.
• W1569876593 hasConcept C86803240 @default.
• W1569876593 hasConceptScore W1569876593C121608353 @default.
• W1569876593 hasConceptScore W1569876593C133307689 @default.
• W1569876593 hasConceptScore W1569876593C142724271 @default.
• W1569876593 hasConceptScore W1569876593C153911025 @default.
• W1569876593 hasConceptScore W1569876593C159047783 @default.
• W1569876593 hasConceptScore W1569876593C2775934546 @default.
• W1569876593 hasConceptScore W1569876593C2776235491 @default.
• W1569876593 hasConceptScore W1569876593C2777343196 @default.
• W1569876593 hasConceptScore W1569876593C2778220009 @default.
• W1569876593 hasConceptScore W1569876593C2779534503 @default.
• W1569876593 hasConceptScore W1569876593C54355233 @default.
• W1569876593 hasConceptScore W1569876593C552990157 @default.
• W1569876593 hasConceptScore W1569876593C71924100 @default.
• W1569876593 hasConceptScore W1569876593C86803240 @default.
• W1569876593 hasIssue "2" @default.
• W1569876593 hasLocation W15698765931 @default.
• W1569876593 hasLocation W15698765932 @default.
• W1569876593 hasLocation W15698765933 @default.
• W1569876593 hasOpenAccess W1569876593 @default.
• W1569876593 hasPrimaryLocation W15698765931 @default.
• W1569876593 hasRelatedWork W173115147 @default.

• next