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• W1569889919 abstract "In the test and treat era of HIV-1 epidemics, it is becoming extremely urgent to detected HIV-1 infected individuals. It is well known that HIV-1 testing enables health care professions to strategize interventions towards interruption of HIV-1 transmission chains, and to implement antiretroviral therapy. Expanding the number of persons treated with antiretroviral potentially decrease the number of new infections.[1] It is very well determined that the available antibodies based assays are very effective in the majority of cases to detect and confirm HIV-1 infection. However, some exceptions do apply. Diagnosis of HIV-1 infection during the so-called immunologic window period, which is the time between the acquisition of HIV infection and the HIV antibody detection, may be of fundamental importance in some specific cases. It has been debated that effective antiretroviral treatment instituted during acute infection period, which occurs during the immunologic window period, may contribute to a better restructuration of the host immune system, thus allowing to a better long term virologic control or to slower pace of disease progression.[2] Detection of infections during the immunologic window period is also a necessity in order to increase the safety of the blood supply. Furthermore, detection of HIV1 infection is not specific enough in the cases where the passive transfer of antibodies occurs, such as among infants born from HIV infected mothers. For all these above applications, the direct identification of the pathogen can be an extremely helpful tool, which can be performed using molecular biology based techniques. It is important to bear in mind that passive transfer of antibodies do not occur exclusively among infant born from HIV positive mothers. In one case, a blood recipient from a seropositive unit did not get infected by HIV, but received antibodies that made anti HIV-EIA and Western-blot positive for a period up to six month, being the western blot profile identical to the one found in the infected blood donor.[3] Other case also showed the immediate detection of donors anti-HIV antibodies following a health care work accident, where a broken blood collection tube injured a nurse.[4]" @default.
• W1569889919 created "2016-06-24" @default.
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• W1569889919 date "2012-01-18" @default.
• W1569889919 modified "2023-09-26" @default.
• W1569889919 title "Nucleic Acid Testing for HIV-1 Diagnosis and Monitoring" @default.
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• W1569889919 doi "https://doi.org/10.5772/29362" @default.
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