FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569924497> ?p ?o ?g. }

• W1569924497 endingPage "7535" @default.
• W1569924497 startingPage "7521" @default.
• W1569924497 abstract "Off-therapy control of viremia by HIV-infected individuals has been associated with two likely players: a restricted viral reservoir and an efficient cell-mediated immune response. We previously showed that a combination of highly suppressive antiretroviral therapy and two experimental drugs, i.e., auranofin and buthionine sulfoximine, was able to reduce the viral reservoir, elicit efficient cell-mediated antiviral responses, and induce intermittent posttherapy viral load control in chronically SIVmac251-infected macaques. We here show that the macaques that had received this drug combination and then stopped antiretroviral therapy were also able to maintain low numbers of activated CD4+ T cells at viral rebound. Moreover, these macaques consistently displayed low-level simian immunodeficiency virus (SIV) diversity, which was in line with the strong and broadly reactive cell-mediated immune responses against conserved Gag antigens. Extended follow-up showed that the two macaques that had received the complete drug combination remained healthy and did not develop AIDS in 2 years of follow-up after therapy suspension. This disease-free survival is longer than twice the average time of progression to AIDS in SIVmac251-infected rhesus macaques. These results suggest that limited numbers of activated T cells at viral rebound and subsequent development of broadly reactive cell-mediated responses may be interrelated in reducing the viral reservoir.The HIV reservoir in CD4+ T cells represents one main obstacle to HIV eradication. Recent studies, however, show that a drastic reduction of this reservoir is insufficient for inducing a functional cure of AIDS. In the present work, we thoroughly studied and subjected to long-term follow-up two macaques showing intermittent control of the virus following suspension of antiretroviral therapy plus an experimental antireservoir treatment, i.e., the gold salt auranofin and the investigational chemotherapeutic agent buthionione sulfoximine (BSO). We found that these drugs were able to decrease the number of activated CD4+ T cells, which are preferential targets for HIV infection. Then, efficient immune responses against the virus were developed in the macaques, which remained healthy during 2 years of follow-up. This result may furnish another building block for future attempts to cure HIV/AIDS." @default.
• W1569924497 created "2016-06-24" @default.
• W1569924497 creator A5004036928 @default.
• W1569924497 creator A5006528347 @default.
• W1569924497 creator A5008502451 @default.
• W1569924497 creator A5020606116 @default.
• W1569924497 creator A5026202265 @default.
• W1569924497 creator A5030284065 @default.
• W1569924497 creator A5031912842 @default.
• W1569924497 creator A5048593024 @default.
• W1569924497 creator A5056602559 @default.
• W1569924497 creator A5066959872 @default.
• W1569924497 creator A5067964875 @default.
• W1569924497 creator A5074401742 @default.
• W1569924497 creator A5075398108 @default.
• W1569924497 creator A5079185884 @default.
• W1569924497 creator A5086510739 @default.
• W1569924497 date "2015-08-01" @default.
• W1569924497 modified "2023-10-01" @default.
• W1569924497 title "Two-Year Follow-Up of Macaques Developing Intermittent Control of the Human Immunodeficiency Virus Homolog Simian Immunodeficiency Virus SIVmac251 in the Chronic Phase of Infection" @default.
• W1569924497 cites W1535828429 @default.
• W1569924497 cites W1964646310 @default.
• W1569924497 cites W1967018933 @default.
• W1569924497 cites W1981459523 @default.
• W1569924497 cites W1981736941 @default.
• W1569924497 cites W1991546715 @default.
• W1569924497 cites W1993891836 @default.
• W1569924497 cites W1996005242 @default.
• W1569924497 cites W1997739963 @default.
• W1569924497 cites W2004798786 @default.
• W1569924497 cites W2005746885 @default.
• W1569924497 cites W2005855976 @default.
• W1569924497 cites W2007130444 @default.
• W1569924497 cites W2016458729 @default.
• W1569924497 cites W2021064626 @default.
• W1569924497 cites W2022692235 @default.
• W1569924497 cites W2025063877 @default.
• W1569924497 cites W2026814484 @default.
• W1569924497 cites W2047300635 @default.
• W1569924497 cites W2050313963 @default.
• W1569924497 cites W2051417236 @default.
• W1569924497 cites W2062935085 @default.
• W1569924497 cites W2063880708 @default.
• W1569924497 cites W2065832117 @default.
• W1569924497 cites W2072794122 @default.
• W1569924497 cites W2075106941 @default.
• W1569924497 cites W2081861662 @default.
• W1569924497 cites W2086082999 @default.
• W1569924497 cites W2087468350 @default.
• W1569924497 cites W2088930409 @default.
• W1569924497 cites W2089806407 @default.
• W1569924497 cites W2090942584 @default.
• W1569924497 cites W2097434562 @default.
• W1569924497 cites W2101419213 @default.
• W1569924497 cites W2115369812 @default.
• W1569924497 cites W2124058652 @default.
• W1569924497 cites W2124114936 @default.
• W1569924497 cites W2125468126 @default.
• W1569924497 cites W2129644115 @default.
• W1569924497 cites W2131460608 @default.
• W1569924497 cites W2138462482 @default.
• W1569924497 cites W2139286515 @default.
• W1569924497 cites W2143314401 @default.
• W1569924497 cites W2146704167 @default.
• W1569924497 cites W2147134928 @default.
• W1569924497 cites W2151940062 @default.
• W1569924497 cites W2162170852 @default.
• W1569924497 cites W2166653928 @default.
• W1569924497 cites W2171178957 @default.
• W1569924497 cites W2171323866 @default.
• W1569924497 doi "https://doi.org/10.1128/jvi.00396-15" @default.
• W1569924497 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4505651" @default.
• W1569924497 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25972547" @default.
• W1569924497 hasPublicationYear "2015" @default.
• W1569924497 type Work @default.
• W1569924497 sameAs 1569924497 @default.
• W1569924497 citedByCount "19" @default.
• W1569924497 countsByYear W15699244972016 @default.
• W1569924497 countsByYear W15699244972017 @default.
• W1569924497 countsByYear W15699244972019 @default.
• W1569924497 countsByYear W15699244972020 @default.
• W1569924497 countsByYear W15699244972021 @default.
• W1569924497 countsByYear W15699244972022 @default.
• W1569924497 countsByYear W15699244972023 @default.
• W1569924497 crossrefType "journal-article" @default.
• W1569924497 hasAuthorship W1569924497A5004036928 @default.
• W1569924497 hasAuthorship W1569924497A5006528347 @default.
• W1569924497 hasAuthorship W1569924497A5008502451 @default.
• W1569924497 hasAuthorship W1569924497A5020606116 @default.
• W1569924497 hasAuthorship W1569924497A5026202265 @default.
• W1569924497 hasAuthorship W1569924497A5030284065 @default.
• W1569924497 hasAuthorship W1569924497A5031912842 @default.
• W1569924497 hasAuthorship W1569924497A5048593024 @default.
• W1569924497 hasAuthorship W1569924497A5056602559 @default.
• W1569924497 hasAuthorship W1569924497A5066959872 @default.
• W1569924497 hasAuthorship W1569924497A5067964875 @default.
• W1569924497 hasAuthorship W1569924497A5074401742 @default.
• W1569924497 hasAuthorship W1569924497A5075398108 @default.

• next