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- W1569930107 abstract "Sheep and lambs were inoculated intracerebrally or subcutaneously with louping-ill virus. In general the severity of symptoms was directly related to the extent of damage to nerve cells. Neuropathological changes in moribund animals were most marked in the Purkinje layer of the cerebellum, the motor nuclei, the vestibular nuclei and the ventral horns of the spinal cord. There was no difference between sheep and lambs in the overall severity of lesions. Purkinje cell loss was most apparent in the ventral parts of the cerebellum of those that were inoculated intracerebrally. The most widely disseminated inflammatory changes were seen in the 2 that succumbed to subcutaneous inoculation. Though the majority of surviving animals showed no neurological symptoms, all had isolated foci of inflammation and neuronophagia throughout the central nervous system. Such lesions were most apparent in the brainstem and spinal cord." @default.
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- W1569930107 date "1971-07-01" @default.
- W1569930107 modified "2023-09-24" @default.
- W1569930107 title "Experimental louping-ill in sheep and lambs" @default.
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- W1569930107 doi "https://doi.org/10.1016/0021-9975(71)90020-x" @default.
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