FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1569936738> ?p ?o ?g. }

• W1569936738 endingPage "687" @default.
• W1569936738 startingPage "681" @default.
• W1569936738 abstract "Background: Long‐term opioid treatment is associated with the development of hyperalgesia. In a rat model we wanted to study if chronic opioid treatment changed the induction and maintenance of spinal long‐term potentiation (LTP), a form of hyperexcitability in the spinal cord. We also wanted to investigate if the clinically available NMDA receptor antagonist ketamine inhibited the effect of chronic opioid treatment on LTP. Methods: The animals were randomized into four groups (saline, morphine 20 mg/kg/day, ketamine 20 mg/kg/day, morphine 20 mg/kg/day and ketamine 20 mg/kg/day). Drugs were given as continuous subcutaneous infusions by means of osmotic minipumps. After 7 days of treatment and during ongoing treatment single unit extracellular recordings were made from the lumbar deep dorsal horn under urethane anesthesia. Single electrical stimuli were applied to the sciatic nerve, and the C‐fiber evoked responses of WDR neurons were recorded before and during 3 h following low frequency (3 Hz) electrical conditioning stimulation. Results: The potentiation of C‐fiber evoked responses by conditioning stimulation was significantly increased in the morphine‐treated group compared to the saline group, while there was no significant difference between the saline, the ketamine and the morphine/ketamine groups. The potentiated responses in the morphine/ketamine group were significantly reduced compared to the morphine group ( P =0.01). Conclusion: Our results indicate that animals treated with long‐term opioid show amplification of stimulus‐induced central sensitisation compared to opioid naïve animals. Ketamine inhibited the morphine‐induced enhancement of LTP, supporting the role of ketamine in prevention of opioid induced hyperalgesia." @default.
• W1569936738 created "2016-06-24" @default.
• W1569936738 creator A5034731444 @default.
• W1569936738 creator A5045817509 @default.
• W1569936738 creator A5065103358 @default.
• W1569936738 date "2008-04-15" @default.
• W1569936738 modified "2023-10-10" @default.
• W1569936738 title "Ketamine blocks enhancement of spinal long-term potentiation in chronic opioid treated rats" @default.
• W1569936738 cites W1483867462 @default.
• W1569936738 cites W1554769608 @default.
• W1569936738 cites W1968901954 @default.
• W1569936738 cites W1988059170 @default.
• W1569936738 cites W1997519202 @default.
• W1569936738 cites W2007156132 @default.
• W1569936738 cites W2009782005 @default.
• W1569936738 cites W2015303667 @default.
• W1569936738 cites W2021160653 @default.
• W1569936738 cites W2023196987 @default.
• W1569936738 cites W2033525233 @default.
• W1569936738 cites W2036507634 @default.
• W1569936738 cites W2036801018 @default.
• W1569936738 cites W2055795908 @default.
• W1569936738 cites W2061373644 @default.
• W1569936738 cites W2068936181 @default.
• W1569936738 cites W2069696287 @default.
• W1569936738 cites W2076150851 @default.
• W1569936738 cites W2079840847 @default.
• W1569936738 cites W2084429447 @default.
• W1569936738 cites W2086042758 @default.
• W1569936738 cites W2093852195 @default.
• W1569936738 cites W2101668638 @default.
• W1569936738 cites W2107040951 @default.
• W1569936738 cites W2109991720 @default.
• W1569936738 cites W2116064885 @default.
• W1569936738 cites W2146958131 @default.
• W1569936738 cites W2152318331 @default.
• W1569936738 cites W2156104538 @default.
• W1569936738 doi "https://doi.org/10.1111/j.1399-6576.2008.01637.x" @default.
• W1569936738 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18419722" @default.
• W1569936738 hasPublicationYear "2008" @default.
• W1569936738 type Work @default.
• W1569936738 sameAs 1569936738 @default.
• W1569936738 citedByCount "30" @default.
• W1569936738 countsByYear W15699367382012 @default.
• W1569936738 countsByYear W15699367382013 @default.
• W1569936738 countsByYear W15699367382014 @default.
• W1569936738 countsByYear W15699367382015 @default.
• W1569936738 countsByYear W15699367382016 @default.
• W1569936738 countsByYear W15699367382017 @default.
• W1569936738 countsByYear W15699367382018 @default.
• W1569936738 countsByYear W15699367382020 @default.
• W1569936738 countsByYear W15699367382021 @default.
• W1569936738 crossrefType "journal-article" @default.
• W1569936738 hasAuthorship W1569936738A5034731444 @default.
• W1569936738 hasAuthorship W1569936738A5045817509 @default.
• W1569936738 hasAuthorship W1569936738A5065103358 @default.
• W1569936738 hasConcept C118552586 @default.
• W1569936738 hasConcept C126322002 @default.
• W1569936738 hasConcept C15490471 @default.
• W1569936738 hasConcept C170493617 @default.
• W1569936738 hasConcept C24998067 @default.
• W1569936738 hasConcept C25274449 @default.
• W1569936738 hasConcept C2777389121 @default.
• W1569936738 hasConcept C2777397205 @default.
• W1569936738 hasConcept C2779245659 @default.
• W1569936738 hasConcept C2780775167 @default.
• W1569936738 hasConcept C2780795376 @default.
• W1569936738 hasConcept C2781063702 @default.
• W1569936738 hasConcept C42219234 @default.
• W1569936738 hasConcept C67018056 @default.
• W1569936738 hasConcept C71924100 @default.
• W1569936738 hasConcept C98274493 @default.
• W1569936738 hasConceptScore W1569936738C118552586 @default.
• W1569936738 hasConceptScore W1569936738C126322002 @default.
• W1569936738 hasConceptScore W1569936738C15490471 @default.
• W1569936738 hasConceptScore W1569936738C170493617 @default.
• W1569936738 hasConceptScore W1569936738C24998067 @default.
• W1569936738 hasConceptScore W1569936738C25274449 @default.
• W1569936738 hasConceptScore W1569936738C2777389121 @default.
• W1569936738 hasConceptScore W1569936738C2777397205 @default.
• W1569936738 hasConceptScore W1569936738C2779245659 @default.
• W1569936738 hasConceptScore W1569936738C2780775167 @default.
• W1569936738 hasConceptScore W1569936738C2780795376 @default.
• W1569936738 hasConceptScore W1569936738C2781063702 @default.
• W1569936738 hasConceptScore W1569936738C42219234 @default.
• W1569936738 hasConceptScore W1569936738C67018056 @default.
• W1569936738 hasConceptScore W1569936738C71924100 @default.
• W1569936738 hasConceptScore W1569936738C98274493 @default.
• W1569936738 hasIssue "5" @default.
• W1569936738 hasLocation W15699367381 @default.
• W1569936738 hasLocation W15699367382 @default.
• W1569936738 hasOpenAccess W1569936738 @default.
• W1569936738 hasPrimaryLocation W15699367381 @default.
• W1569936738 hasRelatedWork W1481764224 @default.
• W1569936738 hasRelatedWork W1973436856 @default.
• W1569936738 hasRelatedWork W1976105490 @default.
• W1569936738 hasRelatedWork W1999612514 @default.
• W1569936738 hasRelatedWork W2014007136 @default.

• next