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- W1569943397 abstract "In women with breast and/or ovarian cancer family history when no molecular testing can be afforded, Dr. Mahajan recommends prophylactic salpingo-oophorectomy (SO) only when a hysterectomy is required for reasons other than malignancy.1 We think that prophylactic SO must be discussed independently of hysterectomy. In women whose first or second degree relative (when the intermediate is a male) has been affected with an ovarian cancer, SO may be proposed at age 50 or 5 years before the onset of ovarian cancer in her relative. This may be discussed either when no BRCA1/2 genetic testing is available or when the gene screening performed for the first time in the family in an index case is negative. Indeed, a negative screening in an index case does not eliminate an undetected BRCA1/2 mutation running in the family. SO may also be discussed in women affected with breast cancer and with a strong family history of breast cancer only (4 cases of breast cancer before 50 years in the same lineage, for example). Indeed, we have estimated that the risk at 70 years of ovarian cancer in these women is above 3%, the threshold for which SO is acceptable according to the French recommendations for the management of women at risk of breast and ovarian cancer.2 Therefore, we agree that SO may be recommended on familial history analysis when BRCA1 and BRCA2 testing is not available. Fatima Laki MD*, Remy Salmon MD*, Dominique Stoppa-Lyonnet MD, PhD , * Department of Surgery, Institut Curie, Paris, France, Department of Genetics, Institut Curie, Paris, France." @default.
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- W1569943397 date "2007-10-29" @default.
- W1569943397 modified "2023-10-14" @default.
- W1569943397 title "Reply to prophylactic salpingo-oophorectomy in a series of 89 women carrying a<i>BRCA1</i>or a<i>BRCA2</i>mutation" @default.
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- W1569943397 doi "https://doi.org/10.1002/cncr.23103" @default.
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