Matches in SemOpenAlex for { <https://semopenalex.org/work/W1570051093> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W1570051093 endingPage "26" @default.
- W1570051093 startingPage "21" @default.
- W1570051093 abstract "A human colon cancer cell line Hce- 8693 was heterotransplanted in nude mice. Polyamine blosythesis Inhibitor a- dlfiuoromethylomithine (DFMO ) show a marked reproducible inhibition in this model. The size and weight of transplanted tumor In DFMO group were smaller than those of the control group and the average inhibition rate was 72.8% (P < 0.001) . DFMO showed higher tumor inhibitory rate than 5-Fu (35. 4%) (P<0. 001) . Furthermore. DFMO demonstrated less severe bone marrow inhibition in the nude mice than 5-Fu (20. 0% Vs 53. 2%. P<0. 001) .There was no synergistic action in these two drugs at the experimental dose. The concentration of putrescine and spermidine in the plasma and tumor tissue in the DFMO group were 70% lower than those of the control group (P<0. 001) . These results indicate that the anti-tumor effect of DFMO might be explained by the inhibition of polyamine biosynthesis and this study provides an experimental basis for future clinical application of DFMO." @default.
- W1570051093 created "2016-06-24" @default.
- W1570051093 creator A5006808819 @default.
- W1570051093 creator A5007173528 @default.
- W1570051093 creator A5012524150 @default.
- W1570051093 creator A5034756933 @default.
- W1570051093 creator A5045328130 @default.
- W1570051093 creator A5076071113 @default.
- W1570051093 date "1991-01-01" @default.
- W1570051093 modified "2023-09-23" @default.
- W1570051093 title "INHIBITORY EFFECT OF DEMO ON THE GROWTH OF TRANSPLANTED HUMAN COLON CANCER IN NUDE MICE" @default.
- W1570051093 hasPublicationYear "1991" @default.
- W1570051093 type Work @default.
- W1570051093 sameAs 1570051093 @default.
- W1570051093 citedByCount "0" @default.
- W1570051093 crossrefType "journal-article" @default.
- W1570051093 hasAuthorship W1570051093A5006808819 @default.
- W1570051093 hasAuthorship W1570051093A5007173528 @default.
- W1570051093 hasAuthorship W1570051093A5012524150 @default.
- W1570051093 hasAuthorship W1570051093A5034756933 @default.
- W1570051093 hasAuthorship W1570051093A5045328130 @default.
- W1570051093 hasAuthorship W1570051093A5076071113 @default.
- W1570051093 hasConcept C121608353 @default.
- W1570051093 hasConcept C126322002 @default.
- W1570051093 hasConcept C17077164 @default.
- W1570051093 hasConcept C181199279 @default.
- W1570051093 hasConcept C185592680 @default.
- W1570051093 hasConcept C2776109719 @default.
- W1570051093 hasConcept C2777167505 @default.
- W1570051093 hasConcept C2777497464 @default.
- W1570051093 hasConcept C2779707156 @default.
- W1570051093 hasConcept C2780115381 @default.
- W1570051093 hasConcept C2780278673 @default.
- W1570051093 hasConcept C502942594 @default.
- W1570051093 hasConcept C526805850 @default.
- W1570051093 hasConcept C55493867 @default.
- W1570051093 hasConcept C62112901 @default.
- W1570051093 hasConcept C71924100 @default.
- W1570051093 hasConcept C86803240 @default.
- W1570051093 hasConceptScore W1570051093C121608353 @default.
- W1570051093 hasConceptScore W1570051093C126322002 @default.
- W1570051093 hasConceptScore W1570051093C17077164 @default.
- W1570051093 hasConceptScore W1570051093C181199279 @default.
- W1570051093 hasConceptScore W1570051093C185592680 @default.
- W1570051093 hasConceptScore W1570051093C2776109719 @default.
- W1570051093 hasConceptScore W1570051093C2777167505 @default.
- W1570051093 hasConceptScore W1570051093C2777497464 @default.
- W1570051093 hasConceptScore W1570051093C2779707156 @default.
- W1570051093 hasConceptScore W1570051093C2780115381 @default.
- W1570051093 hasConceptScore W1570051093C2780278673 @default.
- W1570051093 hasConceptScore W1570051093C502942594 @default.
- W1570051093 hasConceptScore W1570051093C526805850 @default.
- W1570051093 hasConceptScore W1570051093C55493867 @default.
- W1570051093 hasConceptScore W1570051093C62112901 @default.
- W1570051093 hasConceptScore W1570051093C71924100 @default.
- W1570051093 hasConceptScore W1570051093C86803240 @default.
- W1570051093 hasIssue "4" @default.
- W1570051093 hasLocation W15700510931 @default.
- W1570051093 hasOpenAccess W1570051093 @default.
- W1570051093 hasPrimaryLocation W15700510931 @default.
- W1570051093 hasRelatedWork W1554334857 @default.
- W1570051093 hasRelatedWork W1654783469 @default.
- W1570051093 hasRelatedWork W1994117241 @default.
- W1570051093 hasRelatedWork W2001583451 @default.
- W1570051093 hasRelatedWork W2053774894 @default.
- W1570051093 hasRelatedWork W2061531231 @default.
- W1570051093 hasRelatedWork W2083828057 @default.
- W1570051093 hasRelatedWork W2139878455 @default.
- W1570051093 hasRelatedWork W2347572018 @default.
- W1570051093 hasRelatedWork W2354731931 @default.
- W1570051093 hasRelatedWork W2365281818 @default.
- W1570051093 hasRelatedWork W2368792506 @default.
- W1570051093 hasRelatedWork W2369126064 @default.
- W1570051093 hasRelatedWork W2393806413 @default.
- W1570051093 hasRelatedWork W2413786568 @default.
- W1570051093 hasRelatedWork W2413842374 @default.
- W1570051093 hasRelatedWork W2462598136 @default.
- W1570051093 hasRelatedWork W2607958880 @default.
- W1570051093 hasRelatedWork W2886236494 @default.
- W1570051093 hasRelatedWork W1817508758 @default.
- W1570051093 isParatext "false" @default.
- W1570051093 isRetracted "false" @default.
- W1570051093 magId "1570051093" @default.
- W1570051093 workType "article" @default.