Matches in SemOpenAlex for { <https://semopenalex.org/work/W1570125853> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W1570125853 abstract "Abstract : Prolactin receptor (PRLR) is a single transmembrane receptor that normally requires ligand-binding to trigger intracellular signaling. Several isoforms of the human PRLR have been identified, including a long form (LF) and two short forms (SF1a and SF1b). These isoforms share identical amino acid sequence in the extracellular domain, but altered cytoplasmic domain as a consequence of alternative splicing. The extracellular domain consists of two fibronectin-like subdomains, S1 and S2. Recently we have identified the existence of naturally-occurring S2 deleted (delta S2) variants in several human cancer cell lines. We also showed that these human delta S2 isoforms were constitutively dimerized in the absence of PRL. When overexpressed in breast cancer cells, the delta S2 LF increased cell proliferation. The aim of our proposed training grant was to analyze the effect of delta S2 PRLR in a stable transfection system. We found that one of the S2 deleted short isoforms, delta S2 SF1b, was able to inhibit cell growth and migration." @default.
- W1570125853 created "2016-06-24" @default.
- W1570125853 creator A5044564829 @default.
- W1570125853 date "2007-04-01" @default.
- W1570125853 modified "2023-10-16" @default.
- W1570125853 title "The Role of Constitutively Active Prolactin Receptors in the Natural History of Breast Cancer" @default.
- W1570125853 cites W1566261029 @default.
- W1570125853 cites W1600374980 @default.
- W1570125853 cites W1963688341 @default.
- W1570125853 cites W1977366074 @default.
- W1570125853 cites W1979300653 @default.
- W1570125853 cites W1991352513 @default.
- W1570125853 cites W2002302708 @default.
- W1570125853 cites W2003692378 @default.
- W1570125853 cites W2011501880 @default.
- W1570125853 cites W2023523424 @default.
- W1570125853 cites W2024953733 @default.
- W1570125853 cites W2029364552 @default.
- W1570125853 cites W2030601224 @default.
- W1570125853 cites W2088210377 @default.
- W1570125853 cites W2089279843 @default.
- W1570125853 cites W2099328865 @default.
- W1570125853 cites W2106480944 @default.
- W1570125853 cites W2113103296 @default.
- W1570125853 cites W2114128645 @default.
- W1570125853 cites W2120056767 @default.
- W1570125853 cites W2136692995 @default.
- W1570125853 cites W2138287613 @default.
- W1570125853 cites W2142858455 @default.
- W1570125853 cites W2145996190 @default.
- W1570125853 cites W2158842626 @default.
- W1570125853 cites W73721486 @default.
- W1570125853 cites W98308473 @default.
- W1570125853 doi "https://doi.org/10.21236/ada470617" @default.
- W1570125853 hasPublicationYear "2007" @default.
- W1570125853 type Work @default.
- W1570125853 sameAs 1570125853 @default.
- W1570125853 citedByCount "0" @default.
- W1570125853 crossrefType "report" @default.
- W1570125853 hasAuthorship W1570125853A5044564829 @default.
- W1570125853 hasConcept C104317684 @default.
- W1570125853 hasConcept C118892022 @default.
- W1570125853 hasConcept C170493617 @default.
- W1570125853 hasConcept C194583182 @default.
- W1570125853 hasConcept C24530287 @default.
- W1570125853 hasConcept C2779064019 @default.
- W1570125853 hasConcept C2781031661 @default.
- W1570125853 hasConcept C28406088 @default.
- W1570125853 hasConcept C53345823 @default.
- W1570125853 hasConcept C54009773 @default.
- W1570125853 hasConcept C54355233 @default.
- W1570125853 hasConcept C55493867 @default.
- W1570125853 hasConcept C62112901 @default.
- W1570125853 hasConcept C71315377 @default.
- W1570125853 hasConcept C81885089 @default.
- W1570125853 hasConcept C86803240 @default.
- W1570125853 hasConcept C95444343 @default.
- W1570125853 hasConceptScore W1570125853C104317684 @default.
- W1570125853 hasConceptScore W1570125853C118892022 @default.
- W1570125853 hasConceptScore W1570125853C170493617 @default.
- W1570125853 hasConceptScore W1570125853C194583182 @default.
- W1570125853 hasConceptScore W1570125853C24530287 @default.
- W1570125853 hasConceptScore W1570125853C2779064019 @default.
- W1570125853 hasConceptScore W1570125853C2781031661 @default.
- W1570125853 hasConceptScore W1570125853C28406088 @default.
- W1570125853 hasConceptScore W1570125853C53345823 @default.
- W1570125853 hasConceptScore W1570125853C54009773 @default.
- W1570125853 hasConceptScore W1570125853C54355233 @default.
- W1570125853 hasConceptScore W1570125853C55493867 @default.
- W1570125853 hasConceptScore W1570125853C62112901 @default.
- W1570125853 hasConceptScore W1570125853C71315377 @default.
- W1570125853 hasConceptScore W1570125853C81885089 @default.
- W1570125853 hasConceptScore W1570125853C86803240 @default.
- W1570125853 hasConceptScore W1570125853C95444343 @default.
- W1570125853 hasLocation W15701258531 @default.
- W1570125853 hasOpenAccess W1570125853 @default.
- W1570125853 hasPrimaryLocation W15701258531 @default.
- W1570125853 hasRelatedWork W1930942084 @default.
- W1570125853 hasRelatedWork W1963919935 @default.
- W1570125853 hasRelatedWork W1967155978 @default.
- W1570125853 hasRelatedWork W1967844473 @default.
- W1570125853 hasRelatedWork W2020128210 @default.
- W1570125853 hasRelatedWork W2065356213 @default.
- W1570125853 hasRelatedWork W2095071983 @default.
- W1570125853 hasRelatedWork W2114525053 @default.
- W1570125853 hasRelatedWork W2129625801 @default.
- W1570125853 hasRelatedWork W2138055319 @default.
- W1570125853 isParatext "false" @default.
- W1570125853 isRetracted "false" @default.
- W1570125853 magId "1570125853" @default.
- W1570125853 workType "report" @default.