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- W1570166102 startingPage "1913" @default.
- W1570166102 abstract "Abstract IL-4 secreted by activated T cells is a pleiotropic cytokine affecting growth and differentiation of diverse cell types such as T cells, B cells, and mast cells. We investigated the upstream regulatory elements of the human IL-4 promoter. A novel T cell-specific negative regulatory element (NRE) composed of two protein-binding sites were mapped in the 5' flanking region of the IL-4 gene: -311CTCCCTTCT-303 (NRE-I) and -288CTTTTTGCTT-TGC-300 (NRE-II). A T cell-specific protein Neg-1 and a ubiquitous protein Neg-2 binding to NRE-I and NRE-II, respectively, were identified. Furthermore, a positive regulatory element was found 45 bp downstream of the NRE. The enhancer activity of the PRE was completely suppressed when the NRE was present. These data suggest that IL-4 promoter activity is normally down-regulated by an NRE via repression of the enhancer positive regulatory element. These data may have implications for the stringent control of IL-4 expression in T cells." @default.
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- W1570166102 date "1992-03-15" @default.
- W1570166102 modified "2023-09-27" @default.
- W1570166102 title "T cell-specific negative regulation of transcription of the human cytokine IL-4." @default.
- W1570166102 doi "https://doi.org/10.4049/jimmunol.148.6.1913" @default.
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