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- W15702263 abstract "The human genome contains many polymorphic loci known as hypervariable regions (HVR) of DNA, which result from a variable number of tandem repeats of a short core sequence. There are very informative for genetic analysis since there are many alleles at each locus. These regions may occur dispersed throughout the genome, or they may be clustered on a single chromosome. Several HVRs associated with the alpha-globin gene cluster on the short arm of chromosome 16 have been characterized (Higgs et al., 1981). The alpha-globin 3’ HVR (Jarman et al., 1986) is a tandem repeat array of 17 base pairs (pb), the number of which varies considerably between different alleles. Under hybridization conditions of high stringency, the 3’ HVR probe reveals as highly polymorphic locus with heterozygosity approaching 1 (Higgs et al.,1986). The 3’ HVR is a hypervariable region located approximately 8 kb downstream of the al-globin gene; the repeat segment is related to three previously identified HVRs by the sequence 5’— GNGGGG (N) ACAG — 3’; a probe to the 3’ HVR detects multiple, mendelianly inherited DNA segments, suggesting that it too may represent one member of a dispersed minisatel1ite family (Fowler et al., 1986)." @default.
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- W15702263 date "1990-01-01" @default.
- W15702263 modified "2023-09-24" @default.
- W15702263 title "Paternity testing using the hypervariable 3’ HVR DNA probe" @default.
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- W15702263 doi "https://doi.org/10.1007/978-3-642-75496-8_28" @default.
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