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- W1570228086 abstract "Atherosclerosis is a chronic inflammatory disease of the vasculature in which both a disturbed lipid metabolism and inflammatory immune responses against several self-antigens are involved. In this thesis we have explored the effectiveness of DC-immunotherapy in atherosclerosis. We have used different strategies to target the immune component in different stages of atherosclerosis. First we used DCs as a vaccination strategy to induce a protective antibody response trough the injection of oxLDL-pulsed DCs or to target NKT cells by the injection of OCH-pulsed DCs. Next we assessed the potential of DC-immunotherapy in a model of established atherosclerosis. We also evaluated the effects of a disturbed TGF-β signaling in DCs and the subsequent effects on atherosclerosis by using ApoE-/- which have a dysfunctional TGF- Receptor II under the CD11c promoter. Next, we were interested in the effect of foam-cell formation on the antigen-presenting capacity of DCs and macrophages. Therefore we studied the effect of oxLDL-loading on antigen uptake and antigen presentation by DCs and macrophages. Finally, by depleting or inducing Tregs we investigated the potential role of regulatory T cells in a mouse model for aneurysm formation." @default.
- W1570228086 created "2016-06-24" @default.
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- W1570228086 date "2009-12-08" @default.
- W1570228086 modified "2023-09-24" @default.
- W1570228086 title "The potential use of dendritic cells in mouse models of atherosclerosis" @default.
- W1570228086 hasPublicationYear "2009" @default.
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