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• W1570247832 abstract "Gaucher disease (GD) is the most prevalent lysosomal storage disorder. Enzyme replacement therapy (ERT) has demonstrable efficacy in reversing clinical and pathological manifestations of GD. We report four patients with GD and severe hepatic impairment who were successfully treated by orthotopic liver transplantation. Liver failure resulted from GD in two patients and due to a comorbidity in two others (HCV and autoimmune chronic active hepatitis). Following successful liver transplantation, patients received long-term ERT. Liver transplantation is a life-saving treatment for end-stage liver disease in patients with Gaucher disease. All four patients have had excellent outcomes from liver transplantation for up to 10 years postprocedure with no evidence of Gaucher-related pathology in the graft." @default.
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• W1570247832 date "2010-08-01" @default.
• W1570247832 modified "2023-09-27" @default.
• W1570247832 title "Long-Term Outcomes of Liver Transplantation in Type 1 Gaucher Disease" @default.
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• W1570247832 doi "https://doi.org/10.1111/j.1600-6143.2010.03168.x" @default.
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