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- W1570281642 abstract "In this work, facial tricarbonylmanganese(I) complexes [Mn(bpeaCH2C6H4R)(CO)3]PF6 incorporating a functionalized 2,2-bis(pyrazolyl)ethylamine (bpea) ligand with R = I, C≡CH, and CHO have been explored for their utility in bioorthogonal coupling to carrier peptides bearing N-terminal alkyne, azide, and aminoxy residues. As a model system, the transforming growth factor β-recognizing (TGF-β) peptide sequence R′-Leu-Pro-Leu-Gly-Asn-Ser-His-OH was used in which R′ is the reactive group complementary to the metal complex functionality. The use of catalyst-free oxime ligation gave the most stable conjugate with no degradation observed by HPLC over 96 h even after repeated freeze–thaw cycles. Both the parent complex as well as the functionalized peptide were investigated for photoactivated CO delivery to heme proteins by using the myoglobin assay and found to have essentially identical release properties. This work has established a new strategy for the conjugation of photoactivatable CO-releasing molecules (PhotoCORMs) to biological carrier systems." @default.
- W1570281642 created "2016-06-24" @default.
- W1570281642 creator A5056569207 @default.
- W1570281642 creator A5063101017 @default.
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- W1570281642 date "2014-05-16" @default.
- W1570281642 modified "2023-09-25" @default.
- W1570281642 title "Sonogashira, CuAAC, and Oxime Ligations for the Synthesis of Mn <sup>I</sup> Tricarbonyl PhotoCORM Peptide Conjugates" @default.
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- W1570281642 doi "https://doi.org/10.1002/ejic.201402123" @default.
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