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- W1570292923 abstract "An optimal humoral response requires T‐cell help; however, it has been questioned if this help comes exclusively from αβ‐T cells or whether γδ‐T cells also contribute. We have attempted to answer this question by studying the humoral response in T‐cell receptor α‐chain knockout (α –/– ) mice, which lack the αβT cell subset. Two model antigens were used to characterize the response: the thymus‐independent (TI) antigen native dextran B512 (Dx), and the thymus‐dependent (TD) antigen heat shock protein (HSP65) from Mycobacterium tuberculosis . When challenged with Dx, the α –/– mice elicited a strong antibody response and formed rudimentary germinal centres (GCs), a T‐cell dependent reaction. In contrast, the humoral response to HSP65 was poor. However, α –/– mice became primed when challenged with HSP65, because when supplemented with wild‐type thymocytes, the antigen‐primed animals were able to mount a stronger response than the nonprimed ones when challenged with HSP65. A crucial step seems to be the collaboration between γδT cells and antigen presenting cells (APCs), as splenocytes from α –/– mice were able to respond to HSP65 in an environment containing primed‐APCs. Based on these results, we propose a model for B‐cell activation in the α –/– mice." @default.
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- W1570292923 date "2002-03-01" @default.
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- W1570292923 title "The Humoral Response in TCR α<sup>-/-</sup>Mice. Can γδ-T Cells Support the Humoral Immune Response?" @default.
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- W1570292923 doi "https://doi.org/10.1046/j.1365-3083.2002.01045.x" @default.
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