FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1570295746> ?p ?o ?g. }

• W1570295746 endingPage "63" @default.
• W1570295746 startingPage "1" @default.
• W1570295746 abstract "The phenomenon of restriction and modification (R-M) was first observed in the course of studies on bacteriophages in the early 1950s. It was only in the 1960s that work of Arber and colleagues provided a molecular explanation for the host specificity. DNA restriction and modification enzymes are responsible for the host-specific barriers to interstrain and interspecies transfer of genetic information that have been observed in a variety of bacterial cell types. R-M systems comprise an endonuclease and a methyltransferase activity. They serve to protect bacterial cells against bacteriophage infection, because incoming foreign DNA is specifically cleaved by the restriction enzyme if it contains the recognition sequence of the endonuclease. The DNA is protected from cleavage by a specific methylation within the recognition sequence, which is introduced by the methyltransferase. Classic R-M systems are now divided into three types on the basis of enzyme complexity, cofactor requirements, and position of DNA cleavage, although new systems are being discovered that do not fit readily into this classification. This review concentrates on multisubunit, multifunctional ATP-dependent restriction enzymes. A growing number of these enzymes are being subjected to biochemical and genetic studies that, when combined with ongoing structural analyses, promise to provide detailed models for mechanisms of DNA recognition and catalysis. It is now clear that DNA cleavage by these enzymes involves highly unusual modes of interaction between the enzymes and their substrates. These unique features of mechanism pose exciting questions and in addition have led to the suggestion that these enzymes may have biological functions beyond that of restriction and modification. The purpose of this review is to describe the exciting developments in our understanding of how the ATP-dependent restriction enzymes recognize specific DNA sequences and cleave or modify DNA." @default.
• W1570295746 created "2016-06-24" @default.
• W1570295746 creator A5028315481 @default.
• W1570295746 creator A5041421289 @default.
• W1570295746 creator A5051449631 @default.
• W1570295746 date "2000-01-01" @default.
• W1570295746 modified "2023-09-25" @default.
• W1570295746 title "ATP-dependent restriction enzymes" @default.
• W1570295746 cites W117297858 @default.
• W1570295746 cites W1210172792 @default.
• W1570295746 cites W124504601 @default.
• W1570295746 cites W136740849 @default.
• W1570295746 cites W1482346275 @default.
• W1570295746 cites W1484825245 @default.
• W1570295746 cites W1486217288 @default.
• W1570295746 cites W1493801838 @default.
• W1570295746 cites W1498106506 @default.
• W1570295746 cites W1500447870 @default.
• W1570295746 cites W1501779677 @default.
• W1570295746 cites W1503966599 @default.
• W1570295746 cites W1506076499 @default.
• W1570295746 cites W1506085929 @default.
• W1570295746 cites W1506671646 @default.
• W1570295746 cites W1509048326 @default.
• W1570295746 cites W1509498891 @default.
• W1570295746 cites W1514587303 @default.
• W1570295746 cites W1518906504 @default.
• W1570295746 cites W1525549213 @default.
• W1570295746 cites W1525891124 @default.
• W1570295746 cites W1535559134 @default.
• W1570295746 cites W1539949790 @default.
• W1570295746 cites W1543413381 @default.
• W1570295746 cites W1544002077 @default.
• W1570295746 cites W1545118930 @default.
• W1570295746 cites W1545338345 @default.
• W1570295746 cites W1547227838 @default.
• W1570295746 cites W1547417076 @default.
• W1570295746 cites W1557021688 @default.
• W1570295746 cites W1562419683 @default.
• W1570295746 cites W1564791373 @default.
• W1570295746 cites W1576404667 @default.
• W1570295746 cites W1581315186 @default.
• W1570295746 cites W1582475479 @default.
• W1570295746 cites W1586342495 @default.
• W1570295746 cites W1587466397 @default.
• W1570295746 cites W1588090370 @default.
• W1570295746 cites W1589344975 @default.
• W1570295746 cites W1589978035 @default.
• W1570295746 cites W1595640523 @default.
• W1570295746 cites W1604559018 @default.
• W1570295746 cites W1608218663 @default.
• W1570295746 cites W1615493235 @default.
• W1570295746 cites W1663543327 @default.
• W1570295746 cites W1673998910 @default.
• W1570295746 cites W1692805675 @default.
• W1570295746 cites W1696197698 @default.
• W1570295746 cites W1725984708 @default.
• W1570295746 cites W1730159365 @default.
• W1570295746 cites W1738997773 @default.
• W1570295746 cites W1784482614 @default.
• W1570295746 cites W179772329 @default.
• W1570295746 cites W1846272551 @default.
• W1570295746 cites W1853523881 @default.
• W1570295746 cites W1876217832 @default.
• W1570295746 cites W1943268957 @default.
• W1570295746 cites W1965301838 @default.
• W1570295746 cites W1965454340 @default.
• W1570295746 cites W1965633736 @default.
• W1570295746 cites W1965765238 @default.
• W1570295746 cites W1966008495 @default.
• W1570295746 cites W1966595658 @default.
• W1570295746 cites W1967663354 @default.
• W1570295746 cites W1968493153 @default.
• W1570295746 cites W1969866401 @default.
• W1570295746 cites W1970882632 @default.
• W1570295746 cites W1971374540 @default.
• W1570295746 cites W1971403296 @default.
• W1570295746 cites W1971442611 @default.
• W1570295746 cites W1972531948 @default.
• W1570295746 cites W1976720990 @default.
• W1570295746 cites W1977669248 @default.
• W1570295746 cites W1978976606 @default.
• W1570295746 cites W1979541303 @default.
• W1570295746 cites W1980622413 @default.
• W1570295746 cites W1980987126 @default.
• W1570295746 cites W1982625010 @default.
• W1570295746 cites W1982677350 @default.
• W1570295746 cites W1983101161 @default.
• W1570295746 cites W1985776863 @default.
• W1570295746 cites W1986862759 @default.
• W1570295746 cites W1987354384 @default.
• W1570295746 cites W1988180185 @default.
• W1570295746 cites W1990995746 @default.
• W1570295746 cites W1991471459 @default.
• W1570295746 cites W1991845760 @default.
• W1570295746 cites W1991942770 @default.
• W1570295746 cites W1992033009 @default.
• W1570295746 cites W1993451423 @default.

• next