Matches in SemOpenAlex for { <https://semopenalex.org/work/W1570297242> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W1570297242 abstract "NSAID-activated gene-1 (NAG-1) is a cytokine associated with pro-apoptotic and anti-tumorigenic property in colon and lung cancer. Capsaicin, a natural product of the Capsicum species of red peppers, is known to induce apoptosis in colon cancer cells. This study was performed to determine molecular mechanism by which capsaicin activates transactivation of NAG-1 gene in human colorectal cancer cells. Capsaicin increases apoptosis, and up-regulates NAG-1 gene expression at the transcriptional level through C/EBPbeta-mediated pathway. We identified C/EBPbeta binding sites in the NAG-1 promoter responsible for capsaicin-induced NAG-1 transactivation and EMSA and ChIP assay confirmed binding of C/EBPbeta to the NAG-1 promoter. Capsaicin treatment increased C/EBPbeta phosphorylation, and enhanced binding of C/EBPbeta with GSK3beta, and ATF3. Knockdown of C/EBPbeta, GSK3beta or ATF3 ameliorates NAG-1 expression induced by capsaicin treatment. These data indicate that C/EBPbeta phosphorylation through binding to GSK3beta may mediate capsaicin-induced expression of NAG-1 and apoptosis through cooperation with ATF3 in human colorectal cancer cells. Grant Funding Source: NIH, American Cancer Society" @default.
- W1570297242 created "2016-06-24" @default.
- W1570297242 creator A5009464125 @default.
- W1570297242 creator A5014465533 @default.
- W1570297242 creator A5031414863 @default.
- W1570297242 date "2010-04-01" @default.
- W1570297242 modified "2023-09-26" @default.
- W1570297242 title "NSAID‐activated gene‐1 as a molecular target for capsaicin‐induced apoptosis through a novel molecular mechanism involving GSK3beta, C/EBPbeta, and ATF3" @default.
- W1570297242 doi "https://doi.org/10.1096/fasebj.24.1_supplement.928.11" @default.
- W1570297242 hasPublicationYear "2010" @default.
- W1570297242 type Work @default.
- W1570297242 sameAs 1570297242 @default.
- W1570297242 citedByCount "5" @default.
- W1570297242 countsByYear W15702972422014 @default.
- W1570297242 countsByYear W15702972422015 @default.
- W1570297242 countsByYear W15702972422023 @default.
- W1570297242 crossrefType "journal-article" @default.
- W1570297242 hasAuthorship W1570297242A5009464125 @default.
- W1570297242 hasAuthorship W1570297242A5014465533 @default.
- W1570297242 hasAuthorship W1570297242A5031414863 @default.
- W1570297242 hasConcept C101762097 @default.
- W1570297242 hasConcept C104317684 @default.
- W1570297242 hasConcept C1292079 @default.
- W1570297242 hasConcept C150194340 @default.
- W1570297242 hasConcept C153911025 @default.
- W1570297242 hasConcept C157880135 @default.
- W1570297242 hasConcept C170493617 @default.
- W1570297242 hasConcept C173396325 @default.
- W1570297242 hasConcept C185592680 @default.
- W1570297242 hasConcept C190283241 @default.
- W1570297242 hasConcept C2780051329 @default.
- W1570297242 hasConcept C502942594 @default.
- W1570297242 hasConcept C55493867 @default.
- W1570297242 hasConcept C86803240 @default.
- W1570297242 hasConceptScore W1570297242C101762097 @default.
- W1570297242 hasConceptScore W1570297242C104317684 @default.
- W1570297242 hasConceptScore W1570297242C1292079 @default.
- W1570297242 hasConceptScore W1570297242C150194340 @default.
- W1570297242 hasConceptScore W1570297242C153911025 @default.
- W1570297242 hasConceptScore W1570297242C157880135 @default.
- W1570297242 hasConceptScore W1570297242C170493617 @default.
- W1570297242 hasConceptScore W1570297242C173396325 @default.
- W1570297242 hasConceptScore W1570297242C185592680 @default.
- W1570297242 hasConceptScore W1570297242C190283241 @default.
- W1570297242 hasConceptScore W1570297242C2780051329 @default.
- W1570297242 hasConceptScore W1570297242C502942594 @default.
- W1570297242 hasConceptScore W1570297242C55493867 @default.
- W1570297242 hasConceptScore W1570297242C86803240 @default.
- W1570297242 hasIssue "S1" @default.
- W1570297242 hasLocation W15702972421 @default.
- W1570297242 hasOpenAccess W1570297242 @default.
- W1570297242 hasPrimaryLocation W15702972421 @default.
- W1570297242 hasRelatedWork W1570297242 @default.
- W1570297242 hasRelatedWork W1985189742 @default.
- W1570297242 hasRelatedWork W2055256213 @default.
- W1570297242 hasRelatedWork W2479697414 @default.
- W1570297242 hasRelatedWork W2897099802 @default.
- W1570297242 hasRelatedWork W2923518748 @default.
- W1570297242 hasRelatedWork W2947602461 @default.
- W1570297242 hasRelatedWork W3048341121 @default.
- W1570297242 hasRelatedWork W4200413688 @default.
- W1570297242 hasRelatedWork W4285386899 @default.
- W1570297242 hasVolume "24" @default.
- W1570297242 isParatext "false" @default.
- W1570297242 isRetracted "false" @default.
- W1570297242 magId "1570297242" @default.
- W1570297242 workType "article" @default.