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- W1570307628 abstract "Four effects of intravenously injected purified bacterial pyrogens are discussed: 1.1. The induction of a leukopenia within the first hour after injection of the pyrogen. This is followed by a leukocytosis lasting for many hours. 2.2. The induction of fibrinolysis beginning about sixty minutes after the injection and lasting for about ninety minutes. It is caused by the appearance of a great amount of a stable type activator in addition to a small amount of a labile type activator. In vitro experiments and some clinical observations suggest that the leukocytes may be a source of the stable type activator which may be liberated from the leukocytes (and possibly other cells) at the time of development of leukopenia. The activator induces the formation of free plasmin. We found in only a few cases, that another mechanism was responsible for the activation of fibrinolysis, a lysokinase, which induces the formation of a labile type activator. 3.3. Effects on blood coagulation are not caused by the pyrogen itself. The most obvious effect is the development of a hypercoagulability, which could be demonstrated to be a general side effect of the action of proteolytic enzymes in low concentrations. The same effect, but less marked, may be observed after administration of nicotinic acid, small amounts of streptokinase, and trypsin. When the proteolytic activity is fully developed, a digestion of factors v and viii and to a smaller degree of prothrombin and factor vii is observed. Splitting products of fibrinogen cause a distinct antithrombin activity. 4.4. The body temperature is elevated. A period of about ninety minutes after the injection is necessary for the formation of the intrinsic pyrogen which finally causes the rise in temperature. Leukocytes are apparently involved in this transformation." @default.
- W1570307628 created "2016-06-24" @default.
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- W1570307628 date "1960-08-01" @default.
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- W1570307628 title "Pyrogens as thrombolytic agents" @default.
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- W1570307628 doi "https://doi.org/10.1016/0002-9149(60)90334-9" @default.
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