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- W1570308424 abstract "Most of the available drugs act on membrane or nuclear receptors. Membrane receptors desensitize when they undergo an internalization process in response to an excess of agonist. This does not necessarily mean receptor degradation, a process that occurs when endosomes containing internalized receptors fuse with lysosomes, leading to what we call receptor down-regulation. Rather, the internalization of receptors may represent the initial step in retrograde signaling in which the ligand-receptor complex is transported along axons, ultimately leading to longterm effects at the gene level. In neurons, for example, “third messengers” are cytoplasmic proteins which are associated with vesicles containing internalized receptors and which pass into the nucleus. They subsequently serve as transcription factors in the modulation of gene expression. In the future, “third messengers” are expected to be the primary target of new drugs." @default.
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- W1570308424 date "1997-01-01" @default.
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- W1570308424 title "Chapter 24 Genomic pharmacology: From receptor internalization to nuclear translocation of third messengers" @default.
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- W1570308424 doi "https://doi.org/10.1016/s1569-2582(97)80049-9" @default.
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