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- W1570331194 abstract "Summary Biosynthesis of cholesterol and fatty acids, as judged by the incorporation of C 14 from acetate-1-C 14 into these compounds, is affected soon after initiation of the tumorigenic process and is dependent upon the stage of development of the tumor. In the livers of rats with carcinogen-induced tumors, biosynthesis of cholesterol dropped below normal, while the tumor was in its latent form, but increased again when the tumor became visible. In rats and hamsters with transplantable tumors, there was an immediate rise and later a decrease in biosynthesis. Cholesterol biosynthesis in the gastrointestinal tracts and carcasses followed in general the liver patterns. Fatty acid synthesis was only slightly affected in tumor-bearing animals. Cholesterol determinations in the blood of tumor-bearing animals were in agreement with the biosynthesis patterns with the exception of the hepatoma experiment. No significant changes have been observed in the cholesterol contents of tissues of tumor-bearing animals as compared with the normal. Isolated Yoshida ascites tumor cells incubated with acetate-1-C 14 did not synthesize more than traces of cholesterol. Tumors might, however, trap cholesterol." @default.
- W1570331194 created "2016-06-24" @default.
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- W1570331194 date "1958-02-01" @default.
- W1570331194 modified "2023-09-23" @default.
- W1570331194 title "Biosynthesis of cholesterol and fatty acids in tumor-bearing animals." @default.
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