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• W1570331424 abstract "Stimuli-sensitive polymers are very promising and versatile materials for biomedical applications, especially in controlled drug delivery systems (DDS). Controlled DDS provide a therapeutical quality of medicines to the proper site in the body in order to achieve the desired effect with minimum toxicity. DDS are promising in diseases like asthma, cancer, peptic ulcers, cardiovascular ailments, and arthritis. Incorporation of the drug into DDS can protect the active substance against degradation and improve therapeutic effect, control drug release rate, and decrease administration frequency. Polysaccharide-based materials have gained much attention in developing DDS because of their flexibility in obtaining a desirable drug release profile, ease of modification by simple chemical reactions, and broad range of physicochemical properties. The present work concentrates on the design and fabrication of two novel DDS, based on naturally available polysaccharides like chitosan and cellulose, viz. poly(N-vinyl pyrrolidone-co-2-hydroxyethyl methacrylate-co-itaconic acid)-grafted trisodium citrate-crosslinked cellulose acetate-coated chitosan [p-g-CT-Na3Cit-CAc] and poly(acrylic acid-co-acrylamide-co-2-acrylamido-2-methyl-1-propanesulfonic acid)-grafted nanocellulose/poly(vinyl alcohol) composite [P(AA-co-AAm-co-AMPS)-g-NC/PVA]. The drug carriers p-g-CT-Na3Cit-CAc and P(AA-co-AAm-co-AMPS)-g-NC/PVA were used for the in vitro release of 5-fluorouracil (5-FU), an anti-cancer drug and amoxicillin (AMO), an antibacterial agent, respectively. The DDS were well characterized using FTIR, XRD, SEM, and DLS analyses. The swelling capacities of the DDS were optimized by changing the time, temperature, pH, crosslinker density, cellulose acetate (CAc), or poly(vinyl alcohol) (PVA) concentration, and ionic strength of the medium. The marked swelling capacity indicates its biocompatible and nonirritating nature to soft tissues. The drug-loading efficiencies of the DDS were found out by in situ polymerization technique. Drug release studies were carried out in simulated gastric and intestinal fluids and maximum release was observed for intestinal fluid at 37°C. Maximum drug release was observed within 10 and 4 h, respectively, for p-g-CT-Na3Cit-CAc and P(AA-co-AAm-co-AMPS)-g-NC/PVA which suggests that 5-FU can be used in the treatment of colorectal cancer and AMO in the treatment of duodenal ulcer. Drug release kinetic data were evaluated using Ritger Peppas model and found that both diffusion and polymer relaxation contributed to the release of 5-FU and AMO from the DDS. Thus the present work concludes that both the DDS would be fascinating vehicles for the controlled delivery of drugs." @default.
• W1570331424 created "2016-06-24" @default.
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• W1570331424 date "2015-03-12" @default.
• W1570331424 modified "2023-09-27" @default.
• W1570331424 title "Biopolymer-Based Stimuli-Sensitive Functionalized Graft Copolymers as Controlled Drug Delivery Systems" @default.
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• W1570331424 doi "https://doi.org/10.1002/9781119044901.ch12" @default.
• W1570331424 hasPublicationYear "2015" @default.
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