FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1570333985> ?p ?o ?g. }

• W1570333985 endingPage "2838" @default.
• W1570333985 startingPage "2825" @default.
• W1570333985 abstract "The basic electrical rhythmicity of the olivocerebellar system was investigated in vivo using multiple electrode recordings of Purkinje cell (PC) complex spike (CS) activity. CSs demonstrate a 10 Hz rhythmicity, thought to result from the interaction of Ca 2+ and Ca 2+ -dependent K + conductances present in inferior olivary (IO) neurons. To assess the roles of different K + channels in generating this rhythmicity, intraolivary microinjections of charybdotoxin (CTX) and apamin were used. Both K + channel blockers increased average CS spike-firing rates. However, apamin produced a tonic increase in firing with a decrement in the CS rhythmicity. In contrast, after CTX administration, highly rhythmic CS discharges were interleaved with silent periods, suggesting that apamin- and CTX-sensitive K + channels have distinct rhythmogenic roles in IO neurons. CTX-sensitive channels seem to be functionally coupled to low threshold Ca 2+ channels, whereas the apamin-sensitive channels relate to high threshold Ca 2+ channels. Blocking intraolivary GABA A receptors increases IO excitability and the spatial distribution of synchronized CS activity while disrupting its rostrocaudal banding pattern (Lang et al., 1996). The present experiments show that K + channel blockers increase IO excitability without causing widespread synchronization of CS activity. Thus, changes in the IO excitability have relatively little effect in determining the spatial organization of CS synchrony. In contrast, the degree of CS rhythmicity seemed to influence the patterns of CS synchrony. Thus, after CTX, increased CS rhythmicity was associated with increased intraband synchrony and decreased interband synchrony, whereas apamin had the opposite effects on intra- and interband synchronization." @default.
• W1570333985 created "2016-06-24" @default.
• W1570333985 creator A5010754920 @default.
• W1570333985 creator A5045923034 @default.
• W1570333985 creator A5070542812 @default.
• W1570333985 date "1997-04-15" @default.
• W1570333985 modified "2023-09-25" @default.
• W1570333985 title "Differential Roles of Apamin- and Charybdotoxin-Sensitive K⁺Conductances in the Generation of Inferior Olive Rhythmicity<i>In Vivo</i>" @default.
• W1570333985 cites W1266545052 @default.
• W1570333985 cites W1270605176 @default.
• W1570333985 cites W1581158109 @default.
• W1570333985 cites W1695999485 @default.
• W1570333985 cites W1795948620 @default.
• W1570333985 cites W1827142872 @default.
• W1570333985 cites W1968968097 @default.
• W1570333985 cites W1971717952 @default.
• W1570333985 cites W1972246035 @default.
• W1570333985 cites W1979287010 @default.
• W1570333985 cites W1986887981 @default.
• W1570333985 cites W1989226479 @default.
• W1570333985 cites W1989619711 @default.
• W1570333985 cites W1998768631 @default.
• W1570333985 cites W2001901019 @default.
• W1570333985 cites W2003234320 @default.
• W1570333985 cites W2023130165 @default.
• W1570333985 cites W2024642609 @default.
• W1570333985 cites W2025000908 @default.
• W1570333985 cites W2026125311 @default.
• W1570333985 cites W2029266926 @default.
• W1570333985 cites W2029435305 @default.
• W1570333985 cites W2035127927 @default.
• W1570333985 cites W2035438191 @default.
• W1570333985 cites W2040212051 @default.
• W1570333985 cites W2041788443 @default.
• W1570333985 cites W2042431572 @default.
• W1570333985 cites W2048288930 @default.
• W1570333985 cites W2056552455 @default.
• W1570333985 cites W2065842147 @default.
• W1570333985 cites W2079173805 @default.
• W1570333985 cites W2079732522 @default.
• W1570333985 cites W2082304034 @default.
• W1570333985 cites W2087573666 @default.
• W1570333985 cites W2088378593 @default.
• W1570333985 cites W2120284757 @default.
• W1570333985 cites W2167881143 @default.
• W1570333985 cites W2180902327 @default.
• W1570333985 cites W2201624977 @default.
• W1570333985 cites W22185870 @default.
• W1570333985 cites W2400030997 @default.
• W1570333985 cites W2409489789 @default.
• W1570333985 cites W2419299276 @default.
• W1570333985 cites W4211248620 @default.
• W1570333985 doi "https://doi.org/10.1523/jneurosci.17-08-02825.1997" @default.
• W1570333985 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6573100" @default.
• W1570333985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9092604" @default.
• W1570333985 hasPublicationYear "1997" @default.
• W1570333985 type Work @default.
• W1570333985 sameAs 1570333985 @default.
• W1570333985 citedByCount "42" @default.
• W1570333985 countsByYear W15703339852012 @default.
• W1570333985 countsByYear W15703339852013 @default.
• W1570333985 countsByYear W15703339852015 @default.
• W1570333985 countsByYear W15703339852017 @default.
• W1570333985 countsByYear W15703339852018 @default.
• W1570333985 countsByYear W15703339852019 @default.
• W1570333985 countsByYear W15703339852021 @default.
• W1570333985 countsByYear W15703339852023 @default.
• W1570333985 crossrefType "journal-article" @default.
• W1570333985 hasAuthorship W1570333985A5010754920 @default.
• W1570333985 hasAuthorship W1570333985A5045923034 @default.
• W1570333985 hasAuthorship W1570333985A5070542812 @default.
• W1570333985 hasBestOaLocation W15703339851 @default.
• W1570333985 hasConcept C12554922 @default.
• W1570333985 hasConcept C127573956 @default.
• W1570333985 hasConcept C149786707 @default.
• W1570333985 hasConcept C153461711 @default.
• W1570333985 hasConcept C169760540 @default.
• W1570333985 hasConcept C170493617 @default.
• W1570333985 hasConcept C178790620 @default.
• W1570333985 hasConcept C185263204 @default.
• W1570333985 hasConcept C185592680 @default.
• W1570333985 hasConcept C2776919887 @default.
• W1570333985 hasConcept C2780419564 @default.
• W1570333985 hasConcept C50254741 @default.
• W1570333985 hasConcept C519063684 @default.
• W1570333985 hasConcept C55493867 @default.
• W1570333985 hasConcept C83743174 @default.
• W1570333985 hasConcept C86803240 @default.
• W1570333985 hasConceptScore W1570333985C12554922 @default.
• W1570333985 hasConceptScore W1570333985C127573956 @default.
• W1570333985 hasConceptScore W1570333985C149786707 @default.
• W1570333985 hasConceptScore W1570333985C153461711 @default.
• W1570333985 hasConceptScore W1570333985C169760540 @default.
• W1570333985 hasConceptScore W1570333985C170493617 @default.
• W1570333985 hasConceptScore W1570333985C178790620 @default.
• W1570333985 hasConceptScore W1570333985C185263204 @default.
• W1570333985 hasConceptScore W1570333985C185592680 @default.
• W1570333985 hasConceptScore W1570333985C2776919887 @default.

• next