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- W1570346440 abstract "cDNAs encoding human and mouse microtubule-associated protein 4 (MAP 4) were isolated. MAP 4 is encoded by a single gene. Multiple MAP 4 mRNAs are transcribed that are differentially expressed among mouse tissues. Open reading frames for the human and mouse MAP 4 clones indicate three distinct regions consisting of related sequences with different motifs. Approximately 30% of the protein is tandem related repeats of approximately 14 amino acids. Another region contains clusters of serine and proline. Four 18-mer repeats characteristic of the microtubule-binding domains of MAP 2 and tau are located at the carboxyl-terminal portion of MAP 4. Amino acid sequence analysis revealed that human and mouse MAP 4 are homologs of the bovine 190-kDa MAP/MAP U (Aizawa, H., Emori, Y., Murofushi, H., Kawasakai, H., Sakai, H., and Suzuki, K. (1990) J. Biol. Chem. 265, 13849-13855). Mouse and human MAP 4 and the bovine 190-kDa MAP are approximately 75% similar, indicating that these proteins are all members of the same class. Domains with extremely high conservation (greater than or equal to 88%) are: 1) the extreme amino terminus; 2) a proline-rich region between the KDM and S,P domains; 3) the microtubule-binding domain; and 4) the extreme carboxyl terminus." @default.
- W1570346440 created "2016-06-24" @default.
- W1570346440 creator A5037020575 @default.
- W1570346440 creator A5038313388 @default.
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- W1570346440 date "1991-11-01" @default.
- W1570346440 modified "2023-10-16" @default.
- W1570346440 title "A model for microtubule-associated protein 4 structure. Domains defined by comparisons of human, mouse, and bovine sequences." @default.
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- W1570346440 doi "https://doi.org/10.1016/s0021-9258(18)54720-7" @default.
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