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- W1570354793 abstract "Abstract A relatively simple and rapid method has been developed which allows quantitation of the rate of production of single-strand scissions in polydisperse populations of DNA molecules. This method, which is based on determination of the progressive loss of the rapid renaturability (zippering-up) of cross-linked DNA, was applied as a quantitative assay of strand breakage by ionizing radiation and by DNase I. Radiosensitivity to single-strand scissions was proportional to the molecular size but independent of the average base composition or substitution of bromouracil for thymine. The protective effects of cysteine and cysteamine, and self-protection at higher DNA concentrations were demonstrated." @default.
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- W1570354793 date "1967-05-01" @default.
- W1570354793 modified "2023-09-24" @default.
- W1570354793 title "γ-Irradiation of deoxyribonucleic acid in dilute solutions" @default.
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- W1570354793 doi "https://doi.org/10.1016/0022-2836(67)90264-1" @default.
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