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- W1570362517 abstract "Nociceptive nerve endings in muscles are equipped with a multitude of receptor molecules for endogenous pain-producing and sensitizing agents. Particularly interesting for muscle pain are (1) purinergic receptors (e.g. P2X3) activated by adenosine triphosphate (ATP), (2) transient receptor potential vanilloid receptors of subtype 1 (formerly called VR1) activated by protons and heat and (3) tyrosine kinase receptors A activated by nerve growth factor (NGF). ATP is considered a general pain signal, because all cells contain ATP and release it when they are damaged. A low tissue pH is characteristic of many pathological conditions in muscle, such as ischemia and tonic contractions; NGF is released in ischemic and inflamed muscle and has the exceptional property of exciting nociceptive nerve endings exclusively. In the central nervous system, input from muscle nociceptors induces marked neuroplastic changes that result in hyperexcitability and hyperactivity of nociceptive central neurons. This central sensitization is assumed to be responsible for the spontaneous pain and hyperalgesia of patients and is important for the transition from acute to chronic muscle pain. The final step of the transition to chronic pain is characterized by structural changes in neurons and glial cells. A patient with morphological alterations of the nociceptive system is difficult to treat, because the changes need time to normalize." @default.
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- W1570362517 date "2007-01-01" @default.
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- W1570362517 title "Characteristics of Muscle Nociception" @default.
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- W1570362517 doi "https://doi.org/10.1159/000101947" @default.
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