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• W1570372403 abstract "Between half and two thirds of human mortality in developed countries can be attributed to vascular diseases. Financial losses, human sufferings are increasing with aging of the population. Vascular diseases develop when some or many vessels in the body are unable to fulfill their functions. The main function of blood vessels is essentially a mechanical one: to conduct blood. Vessels are functioning in a unique in the body mechanical environment: they are continuously subjected to hemodynamic forces: to shear stress of flowing blood and to distending forces of pressure of the blood in the lumen. Vessels are so much adapted to these hemodynamic forces that it is impossible to understand their physiology, pharmacology and pathology without taking into consideration the unavoidable biomechanical steps in the complicated pathways of cellular and systemic physiological vascular feed-back control loops, to understand vascular drug action and pathomechanism of vascular disease (Lee 2000). Biomechanics is thus at the very core of all vascular sciences. That is reflected in the high number of papers published in the area. 35 000 papers listed in the Ovid Medline between 1948 and 2010 included knowledge on vascular mechanics in its narrower sense (excluding papers dealing only with physiological and pharmacological means of vascular smooth muscle control). Deteriorating Windkessel function of the aged, of the chronic hypertensive, even after effective treatment of mean arterial pressure, geometric, biomechanical consequences of atheroscerotic focal remodeling of large arteries, contractile and elastic remodeling of resistance arteries with aging, with hypertension and with diabetes, remodeling of venous networks and the venous wall in chronic venous disease, inevitably draws the attention of clinicians and of pathologists to biomechanical questions. Recent developments in vascular mechanics, backed with many methodical improvements in the field (Berczi 2005, Cox 1974, Duling 1981, Huotari 2010, Mersich 2005, Nadasy 2001, Shimazu 1986, See Fig. 1.), integration of these results into the context of reliable older knowledge makes now a systemic overview of the most important aspects of vascular mechanics possible. We will see that an almost axiomatic approach to a phenomenological description of vascular biomechanics is now in sight. Methodical advancement in the field of cellular physiology, histochemistry and biochemistry (Discher 2009) identified many if not all extraand intracellular fiber types and molecules contributing to the biomechanics of the vascular wall. Mechanical factors in intraand extracellular fiber protein expression control are just being identified. The emerging debate whether mechanics or biochemistry controls vascular" @default.
• W1570372403 created "2016-06-24" @default.
• W1570372403 creator A5028916660 @default.
• W1570372403 date "2012-01-05" @default.
• W1570372403 modified "2023-10-01" @default.
• W1570372403 title "Elements of Vascular Mechanics" @default.
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