FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1570379221> ?p ?o ?g. }

• W1570379221 endingPage "8175" @default.
• W1570379221 startingPage "8168" @default.
• W1570379221 abstract "Abstract Allergy represents a hypersensitivity disease that affects &gt;25% of the population in industrialized countries. The underlying type I allergic immune reaction occurs in predisposed atopic individuals in response to otherwise harmless Ags (i.e., allergens) and is characterized by the production of allergen-specific IgE, an allergen-specific T cell response, and the release of biologically active mediators such as histamine from mast cells and basophils. Regimens permanently tolerizing an allergic immune response still need to be developed. We therefore retrovirally transduced murine hematopoietic stem cells to express the major grass pollen allergen Phl p 5 on their cell membrane. Transplantation of these genetically modified hematopoietic stem cells led to durable multilineage molecular chimerism and permanent immunological tolerance toward the introduced allergen at the B cell, T cell, and effector cell levels. Notably, Phl p 5-specific serum IgE and IgG remained undetectable, and T cell nonresponsiveness persisted throughout follow-up (40 wk). Besides, mediator release was specifically absent in in vitro and in vivo assays. B cell, T cell, and effector cell responses to an unrelated control allergen (Bet v 1) were unperturbed, demonstrating specificity of this tolerance protocol. We thus describe a novel cell-based strategy for the prevention of allergy." @default.
• W1570379221 created "2016-06-24" @default.
• W1570379221 creator A5008672521 @default.
• W1570379221 creator A5017322328 @default.
• W1570379221 creator A5045314207 @default.
• W1570379221 creator A5050048947 @default.
• W1570379221 creator A5055817938 @default.
• W1570379221 creator A5056359769 @default.
• W1570379221 creator A5067188280 @default.
• W1570379221 creator A5068057349 @default.
• W1570379221 creator A5084819048 @default.
• W1570379221 date "2008-06-15" @default.
• W1570379221 modified "2023-10-01" @default.
• W1570379221 title "Tolerization of a Type I Allergic Immune Response through Transplantation of Genetically Modified Hematopoietic Stem Cells" @default.
• W1570379221 cites W1504210864 @default.
• W1570379221 cites W1527104786 @default.
• W1570379221 cites W1548356984 @default.
• W1570379221 cites W1613618419 @default.
• W1570379221 cites W1837912440 @default.
• W1570379221 cites W1958142025 @default.
• W1570379221 cites W1981150156 @default.
• W1570379221 cites W1991925617 @default.
• W1570379221 cites W1992996651 @default.
• W1570379221 cites W1994497303 @default.
• W1570379221 cites W1997268400 @default.
• W1570379221 cites W1999585440 @default.
• W1570379221 cites W2000702115 @default.
• W1570379221 cites W2015401685 @default.
• W1570379221 cites W2024875691 @default.
• W1570379221 cites W2027284518 @default.
• W1570379221 cites W2030194393 @default.
• W1570379221 cites W2043515742 @default.
• W1570379221 cites W2047774290 @default.
• W1570379221 cites W2049997594 @default.
• W1570379221 cites W2052063445 @default.
• W1570379221 cites W2059405890 @default.
• W1570379221 cites W2060913542 @default.
• W1570379221 cites W2064180188 @default.
• W1570379221 cites W2064793834 @default.
• W1570379221 cites W2065619967 @default.
• W1570379221 cites W2066352783 @default.
• W1570379221 cites W2067065957 @default.
• W1570379221 cites W2068105061 @default.
• W1570379221 cites W2069010833 @default.
• W1570379221 cites W2070081797 @default.
• W1570379221 cites W2078702573 @default.
• W1570379221 cites W2079803299 @default.
• W1570379221 cites W2080761418 @default.
• W1570379221 cites W2085736652 @default.
• W1570379221 cites W2097810228 @default.
• W1570379221 cites W2105204567 @default.
• W1570379221 cites W2109311654 @default.
• W1570379221 cites W2110727393 @default.
• W1570379221 cites W2113707325 @default.
• W1570379221 cites W2119324304 @default.
• W1570379221 cites W2122478390 @default.
• W1570379221 cites W2159749046 @default.
• W1570379221 cites W2160666689 @default.
• W1570379221 cites W2161792071 @default.
• W1570379221 cites W2164035061 @default.
• W1570379221 cites W2167234191 @default.
• W1570379221 cites W4237567990 @default.
• W1570379221 cites W4237691003 @default.
• W1570379221 cites W4253611909 @default.
• W1570379221 cites W4362204021 @default.
• W1570379221 cites W3151452517 @default.
• W1570379221 doi "https://doi.org/10.4049/jimmunol.180.12.8168" @default.
• W1570379221 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2993923" @default.
• W1570379221 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18523282" @default.
• W1570379221 hasPublicationYear "2008" @default.
• W1570379221 type Work @default.
• W1570379221 sameAs 1570379221 @default.
• W1570379221 citedByCount "37" @default.
• W1570379221 countsByYear W15703792212012 @default.
• W1570379221 countsByYear W15703792212013 @default.
• W1570379221 countsByYear W15703792212015 @default.
• W1570379221 countsByYear W15703792212016 @default.
• W1570379221 countsByYear W15703792212017 @default.
• W1570379221 countsByYear W15703792212018 @default.
• W1570379221 countsByYear W15703792212019 @default.
• W1570379221 countsByYear W15703792212020 @default.
• W1570379221 countsByYear W15703792212023 @default.
• W1570379221 crossrefType "journal-article" @default.
• W1570379221 hasAuthorship W1570379221A5008672521 @default.
• W1570379221 hasAuthorship W1570379221A5017322328 @default.
• W1570379221 hasAuthorship W1570379221A5045314207 @default.
• W1570379221 hasAuthorship W1570379221A5050048947 @default.
• W1570379221 hasAuthorship W1570379221A5055817938 @default.
• W1570379221 hasAuthorship W1570379221A5056359769 @default.
• W1570379221 hasAuthorship W1570379221A5067188280 @default.
• W1570379221 hasAuthorship W1570379221A5068057349 @default.
• W1570379221 hasAuthorship W1570379221A5084819048 @default.
• W1570379221 hasBestOaLocation W15703792211 @default.
• W1570379221 hasConcept C109159458 @default.
• W1570379221 hasConcept C126322002 @default.
• W1570379221 hasConcept C141105273 @default.
• W1570379221 hasConcept C159654299 @default.
• W1570379221 hasConcept C203014093 @default.

• next