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- W1570385204 abstract "We consider a two-arm sequential trial with two or more strata. The trial is monitored and terminated under the assumption of a common treatment effect (if any) in all strata. A secondary question at the end of the trial is: Does the treatment effect differ across strata?that is, is there a treatment x stratum interaction? We provide a test of the null hypothesis of no interaction?a test that recognizes the sequential stopping rule and allows for uneven accumulation of information in the various strata, a common case. In the case of two strata, and either a group-sequential design or a fully-sequential linear-boundary design, an optimal property of the test is derived. A computational algorithm is provided, and two examples summarized." @default.
- W1570385204 created "2016-06-24" @default.
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- W1570385204 date "2003-01-01" @default.
- W1570385204 modified "2023-09-23" @default.
- W1570385204 title "Testing for a treatment-by-stratum interaction in a sequential clinical trial" @default.
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- W1570385204 doi "https://doi.org/10.1214/lnms/1215092386" @default.
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