Matches in SemOpenAlex for { <https://semopenalex.org/work/W1570385659> ?p ?o ?g. }
- W1570385659 endingPage "58" @default.
- W1570385659 startingPage "1148" @default.
- W1570385659 abstract "Considering that integrins may play a major role in the localization in distinct biological features as well as in the dissemination of several types of lymphomas, we studied the expression of the monoclonal antibody HML-1-defined alpha E beta 7 integrin (CD103) in the clinically and histologically determined stages of 53 mycosis fungoides (MF) skin biopsies and in 16 affected lymph nodes. Immunoperoxidase staining revealed HML-1 immunoreactivity with T cells in the early stages of disease (patch and plaque stage MF). HML-1 expression was more pronounced on infiltrating epidermal than on dermal T cells. In contrast to early stages, tumor stage MF and lymph nodes affected in the course of cutaneous T cell lymphoma were HML-1 negative. We found a strong association between HML-1 expression, epidermotropism of infiltrating T cells, and the stage of disease. We provide evidence that: 1) the loss of the HML-1 antigen on T cells in MF is a marker of poor prognosis and 2) because the HML-1 antigen is selectively expressed on T lymphocytes of epithelial sites such as gut and skin, our results are compatible with the view that alpha E beta 7 integrins perform homing receptor functions for epitheliotropic T cells." @default.
- W1570385659 created "2016-06-24" @default.
- W1570385659 creator A5012483397 @default.
- W1570385659 creator A5026953073 @default.
- W1570385659 creator A5087346246 @default.
- W1570385659 creator A5091413654 @default.
- W1570385659 date "1994-11-01" @default.
- W1570385659 modified "2023-09-23" @default.
- W1570385659 title "Expression of monoclonal antibody HML-1-defined alpha E beta 7 integrin in cutaneous T cell lymphoma." @default.
- W1570385659 cites W1483614591 @default.
- W1570385659 cites W1505054886 @default.
- W1570385659 cites W1516764906 @default.
- W1570385659 cites W1536401060 @default.
- W1570385659 cites W1536714890 @default.
- W1570385659 cites W1539918393 @default.
- W1570385659 cites W1551282315 @default.
- W1570385659 cites W1591707250 @default.
- W1570385659 cites W1725733270 @default.
- W1570385659 cites W1966286149 @default.
- W1570385659 cites W1969060754 @default.
- W1570385659 cites W1972866849 @default.
- W1570385659 cites W1975163371 @default.
- W1570385659 cites W1978340822 @default.
- W1570385659 cites W1982821067 @default.
- W1570385659 cites W1989596114 @default.
- W1570385659 cites W1993110107 @default.
- W1570385659 cites W2000003230 @default.
- W1570385659 cites W2002774826 @default.
- W1570385659 cites W2013381560 @default.
- W1570385659 cites W2014353123 @default.
- W1570385659 cites W2026500691 @default.
- W1570385659 cites W2028418732 @default.
- W1570385659 cites W2033018213 @default.
- W1570385659 cites W2034224535 @default.
- W1570385659 cites W2043835963 @default.
- W1570385659 cites W2057824616 @default.
- W1570385659 cites W2066317510 @default.
- W1570385659 cites W2067853171 @default.
- W1570385659 cites W2073462909 @default.
- W1570385659 cites W2077235937 @default.
- W1570385659 cites W2085875957 @default.
- W1570385659 cites W2106125969 @default.
- W1570385659 cites W2133147332 @default.
- W1570385659 cites W2141850713 @default.
- W1570385659 cites W2154365842 @default.
- W1570385659 cites W2161408348 @default.
- W1570385659 cites W2218385946 @default.
- W1570385659 cites W2405304523 @default.
- W1570385659 cites W2548644018 @default.
- W1570385659 cites W4211085708 @default.
- W1570385659 cites W55913209 @default.
- W1570385659 cites W2413670317 @default.
- W1570385659 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1887437" @default.
- W1570385659 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7977645" @default.
- W1570385659 hasPublicationYear "1994" @default.
- W1570385659 type Work @default.
- W1570385659 sameAs 1570385659 @default.
- W1570385659 citedByCount "5" @default.
- W1570385659 crossrefType "journal-article" @default.
- W1570385659 hasAuthorship W1570385659A5012483397 @default.
- W1570385659 hasAuthorship W1570385659A5026953073 @default.
- W1570385659 hasAuthorship W1570385659A5087346246 @default.
- W1570385659 hasAuthorship W1570385659A5091413654 @default.
- W1570385659 hasConcept C128102431 @default.
- W1570385659 hasConcept C142724271 @default.
- W1570385659 hasConcept C147483822 @default.
- W1570385659 hasConcept C1491633281 @default.
- W1570385659 hasConcept C159654299 @default.
- W1570385659 hasConcept C195687474 @default.
- W1570385659 hasConcept C203014093 @default.
- W1570385659 hasConcept C2776780870 @default.
- W1570385659 hasConcept C2777756187 @default.
- W1570385659 hasConcept C2779338263 @default.
- W1570385659 hasConcept C2779720271 @default.
- W1570385659 hasConcept C2992881475 @default.
- W1570385659 hasConcept C542903549 @default.
- W1570385659 hasConcept C54355233 @default.
- W1570385659 hasConcept C71924100 @default.
- W1570385659 hasConcept C86803240 @default.
- W1570385659 hasConceptScore W1570385659C128102431 @default.
- W1570385659 hasConceptScore W1570385659C142724271 @default.
- W1570385659 hasConceptScore W1570385659C147483822 @default.
- W1570385659 hasConceptScore W1570385659C1491633281 @default.
- W1570385659 hasConceptScore W1570385659C159654299 @default.
- W1570385659 hasConceptScore W1570385659C195687474 @default.
- W1570385659 hasConceptScore W1570385659C203014093 @default.
- W1570385659 hasConceptScore W1570385659C2776780870 @default.
- W1570385659 hasConceptScore W1570385659C2777756187 @default.
- W1570385659 hasConceptScore W1570385659C2779338263 @default.
- W1570385659 hasConceptScore W1570385659C2779720271 @default.
- W1570385659 hasConceptScore W1570385659C2992881475 @default.
- W1570385659 hasConceptScore W1570385659C542903549 @default.
- W1570385659 hasConceptScore W1570385659C54355233 @default.
- W1570385659 hasConceptScore W1570385659C71924100 @default.
- W1570385659 hasConceptScore W1570385659C86803240 @default.
- W1570385659 hasIssue "5" @default.
- W1570385659 hasLocation W15703856591 @default.
- W1570385659 hasOpenAccess W1570385659 @default.