FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1570409822> ?p ?o ?g. }

• W1570409822 endingPage "204" @default.
• W1570409822 startingPage "195" @default.
• W1570409822 abstract "Bacteria tune the function of their ribosomes by methylating specific rRNA nucleotides. Nucleotide G745 in Escherichia coli 23S rRNA is methylated by the methyltransferase enzyme RrmA, whereas in Streptomyces fradiae, the neighbouring nucleotide G748 is methylated by the enzyme TlrB. Both nucleotides line the peptide exit channel of the ribosome at the binding site of macrolide, lincosamide and streptogramin B antibiotics. Resistance to the macrolide tylosin, which is produced by S. fradiae, is conferred by methylation of G748. RrmA and TlrB are homologues (29% identical), and a database search against all presently available sequences revealed a further two dozen homologues from a wide variety of Bacteria. No homologues were found among the Archaea or Eukarya. The bacterial sequences adhere to the species phylogeny and segregate into two groups, in which the Gramnegative sequences align with RrmA and the Gram-positives with TlrB. Consistently, in more than 20 species tested, the distribution of methylation in the Gram-negative rRNAs (methylated at G745) and the Gram-positives (methylated at G748) perfectly matches the bacterial phylogeny. Cloning and ex-pression of representative methyltransferase genes showed that this specificity of methylation is determined solely by the methyltransferase enzyme and is independent of the origin of the rRNA substrate. This is the first case in which the position of an RNA methylation defines a sharp division between the Gram-negative and Gram-positive bacteria. Given the specificities and distribution of these methyltransferases, we propose a change in the nomenclature of RrmA to RlmAI (rRNA large subunit methyltransferase) and of TlrB to RlmAII." @default.
• W1570409822 created "2016-06-24" @default.
• W1570409822 creator A5053616262 @default.
• W1570409822 creator A5080286294 @default.
• W1570409822 date "2002-04-20" @default.
• W1570409822 modified "2023-09-23" @default.
• W1570409822 title "Methylation at nucleotide G745 or G748 in 23S rRNA distinguishes Gram-negative from Gram-positive bacteria" @default.
• W1570409822 cites W1593204696 @default.
• W1570409822 cites W1800445109 @default.
• W1570409822 cites W1929550892 @default.
• W1570409822 cites W1931683448 @default.
• W1570409822 cites W1963946970 @default.
• W1570409822 cites W1973021684 @default.
• W1570409822 cites W1977010109 @default.
• W1570409822 cites W1981562747 @default.
• W1570409822 cites W1983534198 @default.
• W1570409822 cites W1987827036 @default.
• W1570409822 cites W1988017690 @default.
• W1570409822 cites W2012104775 @default.
• W1570409822 cites W2014521800 @default.
• W1570409822 cites W2025168003 @default.
• W1570409822 cites W2031797010 @default.
• W1570409822 cites W2034933171 @default.
• W1570409822 cites W2036787271 @default.
• W1570409822 cites W2037129989 @default.
• W1570409822 cites W2039026588 @default.
• W1570409822 cites W2043158848 @default.
• W1570409822 cites W2059725683 @default.
• W1570409822 cites W2065666222 @default.
• W1570409822 cites W2087679230 @default.
• W1570409822 cites W2092617311 @default.
• W1570409822 cites W2093471887 @default.
• W1570409822 cites W2096715896 @default.
• W1570409822 cites W2100926646 @default.
• W1570409822 cites W2106882534 @default.
• W1570409822 cites W2114433875 @default.
• W1570409822 cites W2119544741 @default.
• W1570409822 cites W2119966574 @default.
• W1570409822 cites W2121234754 @default.
• W1570409822 cites W2125498037 @default.
• W1570409822 cites W2132740573 @default.
• W1570409822 cites W2135493947 @default.
• W1570409822 cites W2155060633 @default.
• W1570409822 cites W2158714788 @default.
• W1570409822 cites W2166117980 @default.
• W1570409822 cites W2166865790 @default.
• W1570409822 cites W2169351558 @default.
• W1570409822 cites W991864014 @default.
• W1570409822 doi "https://doi.org/10.1046/j.1365-2958.2002.02866.x" @default.
• W1570409822 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11967079" @default.
• W1570409822 hasPublicationYear "2002" @default.
• W1570409822 type Work @default.
• W1570409822 sameAs 1570409822 @default.
• W1570409822 citedByCount "35" @default.
• W1570409822 countsByYear W15704098222012 @default.
• W1570409822 countsByYear W15704098222013 @default.
• W1570409822 countsByYear W15704098222014 @default.
• W1570409822 countsByYear W15704098222015 @default.
• W1570409822 countsByYear W15704098222016 @default.
• W1570409822 countsByYear W15704098222018 @default.
• W1570409822 countsByYear W15704098222019 @default.
• W1570409822 countsByYear W15704098222020 @default.
• W1570409822 countsByYear W15704098222021 @default.
• W1570409822 countsByYear W15704098222023 @default.
• W1570409822 crossrefType "journal-article" @default.
• W1570409822 hasAuthorship W1570409822A5053616262 @default.
• W1570409822 hasAuthorship W1570409822A5080286294 @default.
• W1570409822 hasBestOaLocation W15704098221 @default.
• W1570409822 hasConcept C104317684 @default.
• W1570409822 hasConcept C2776060363 @default.
• W1570409822 hasConcept C2777321828 @default.
• W1570409822 hasConcept C2779920670 @default.
• W1570409822 hasConcept C2909856833 @default.
• W1570409822 hasConcept C33288867 @default.
• W1570409822 hasConcept C40749294 @default.
• W1570409822 hasConcept C523546767 @default.
• W1570409822 hasConcept C54355233 @default.
• W1570409822 hasConcept C55493867 @default.
• W1570409822 hasConcept C67705224 @default.
• W1570409822 hasConcept C67905577 @default.
• W1570409822 hasConcept C86803240 @default.
• W1570409822 hasConcept C88478588 @default.
• W1570409822 hasConcept C91965660 @default.
• W1570409822 hasConceptScore W1570409822C104317684 @default.
• W1570409822 hasConceptScore W1570409822C2776060363 @default.
• W1570409822 hasConceptScore W1570409822C2777321828 @default.
• W1570409822 hasConceptScore W1570409822C2779920670 @default.
• W1570409822 hasConceptScore W1570409822C2909856833 @default.
• W1570409822 hasConceptScore W1570409822C33288867 @default.
• W1570409822 hasConceptScore W1570409822C40749294 @default.
• W1570409822 hasConceptScore W1570409822C523546767 @default.
• W1570409822 hasConceptScore W1570409822C54355233 @default.
• W1570409822 hasConceptScore W1570409822C55493867 @default.
• W1570409822 hasConceptScore W1570409822C67705224 @default.
• W1570409822 hasConceptScore W1570409822C67905577 @default.
• W1570409822 hasConceptScore W1570409822C86803240 @default.
• W1570409822 hasConceptScore W1570409822C88478588 @default.
• W1570409822 hasConceptScore W1570409822C91965660 @default.

• next