Matches in SemOpenAlex for { <https://semopenalex.org/work/W1570452496> ?p ?o ?g. }
- W1570452496 endingPage "18925" @default.
- W1570452496 startingPage "18921" @default.
- W1570452496 abstract "Abstract To study the regulation of nuclear genes which encode mitochondrial enzymes involved in oxidative metabolism, absolute levels of mRNA encoding rat medium chain acyl-CoA dehydrogenase (MCAD) and rat mitochondrial malate dehydrogenase (mMDH) were determined in developing and adult male rat tissues. MCAD mRNA is expressed in a variety of adult male tissues with highest steady state levels in heart, adrenal, and skeletal muscle and lowest levels in brain, lung, and testes. In comparison, steady state levels of mMDH mRNA in adult male rat tissues were similar to those of MCAD mRNA in heart, small intestine, adrenal, and skeletal muscle but markedly different in brain, stomach, and testes. Thus, the steady-state levels of MCAD and mMDH mRNA are highest in adult tissues with high energy requirements. Dot blot analysis of RNA prepared from late fetal, suckling, and weaning rat heart, liver, and brain demonstrated the presence of MCAD and mMDH mRNA during the fetal period in all three tissues. Both MCAD and mMDH mRNA levels increased 2-2.5-fold at birth followed by a decline during the first postnatal week in heart and liver. The patterns of accumulation of these mRNAs in heart and liver during the weaning and early adult periods were also similar, although the absolute levels were significantly different. Brain MCAD mRNA levels were consistently low (less than 0.1 pg/micrograms total cellular RNA) throughout the developmental stages. However, brain mMDH mRNA levels exhibited a marked increase during the weaning period, reaching a peak concentration which is higher than the level of mMDH mRNA in heart and liver at any point during development. These results indicate that the level of expression of the nuclear genes encoding MCAD and mMDH is tissue-specific and developmentally regulated. The patterns of MCAD and mMDH mRNA accumulation parallel the changes in energy metabolism which occur during development and among adult tissues." @default.
- W1570452496 created "2016-06-24" @default.
- W1570452496 creator A5028299159 @default.
- W1570452496 creator A5053088251 @default.
- W1570452496 creator A5053385911 @default.
- W1570452496 creator A5063884903 @default.
- W1570452496 date "1989-11-01" @default.
- W1570452496 modified "2023-10-01" @default.
- W1570452496 title "The Tissue-specific Expression and Developmental Regulation of Two Nuclear Genes Encoding Rat Mitochondrial Proteins" @default.
- W1570452496 cites W1426433934 @default.
- W1570452496 cites W1488455175 @default.
- W1570452496 cites W1498468770 @default.
- W1570452496 cites W1503509538 @default.
- W1570452496 cites W1519900170 @default.
- W1570452496 cites W1548460103 @default.
- W1570452496 cites W1583078219 @default.
- W1570452496 cites W1917787915 @default.
- W1570452496 cites W1973907000 @default.
- W1570452496 cites W1979759472 @default.
- W1570452496 cites W1985504383 @default.
- W1570452496 cites W1999134728 @default.
- W1570452496 cites W2001725682 @default.
- W1570452496 cites W2022701588 @default.
- W1570452496 cites W2032110948 @default.
- W1570452496 cites W2037432346 @default.
- W1570452496 cites W2048747979 @default.
- W1570452496 cites W2057887687 @default.
- W1570452496 cites W2060333964 @default.
- W1570452496 cites W2076535868 @default.
- W1570452496 cites W2086545994 @default.
- W1570452496 cites W2086587567 @default.
- W1570452496 cites W2099273349 @default.
- W1570452496 cites W2138270253 @default.
- W1570452496 cites W2182175785 @default.
- W1570452496 cites W2336299664 @default.
- W1570452496 cites W3025642248 @default.
- W1570452496 doi "https://doi.org/10.1016/s0021-9258(19)47245-1" @default.
- W1570452496 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2808399" @default.
- W1570452496 hasPublicationYear "1989" @default.
- W1570452496 type Work @default.
- W1570452496 sameAs 1570452496 @default.
- W1570452496 citedByCount "115" @default.
- W1570452496 countsByYear W15704524962012 @default.
- W1570452496 countsByYear W15704524962013 @default.
- W1570452496 countsByYear W15704524962014 @default.
- W1570452496 countsByYear W15704524962015 @default.
- W1570452496 countsByYear W15704524962020 @default.
- W1570452496 countsByYear W15704524962021 @default.
- W1570452496 countsByYear W15704524962022 @default.
- W1570452496 crossrefType "journal-article" @default.
- W1570452496 hasAuthorship W1570452496A5028299159 @default.
- W1570452496 hasAuthorship W1570452496A5053088251 @default.
- W1570452496 hasAuthorship W1570452496A5053385911 @default.
- W1570452496 hasAuthorship W1570452496A5063884903 @default.
- W1570452496 hasBestOaLocation W15704524961 @default.
- W1570452496 hasConcept C104317684 @default.
- W1570452496 hasConcept C105580179 @default.
- W1570452496 hasConcept C126322002 @default.
- W1570452496 hasConcept C132901563 @default.
- W1570452496 hasConcept C134018914 @default.
- W1570452496 hasConcept C150194340 @default.
- W1570452496 hasConcept C153911025 @default.
- W1570452496 hasConcept C172680121 @default.
- W1570452496 hasConcept C177707886 @default.
- W1570452496 hasConcept C181199279 @default.
- W1570452496 hasConcept C2779234561 @default.
- W1570452496 hasConcept C2781330172 @default.
- W1570452496 hasConcept C28859421 @default.
- W1570452496 hasConcept C54355233 @default.
- W1570452496 hasConcept C55493867 @default.
- W1570452496 hasConcept C71924100 @default.
- W1570452496 hasConcept C86803240 @default.
- W1570452496 hasConceptScore W1570452496C104317684 @default.
- W1570452496 hasConceptScore W1570452496C105580179 @default.
- W1570452496 hasConceptScore W1570452496C126322002 @default.
- W1570452496 hasConceptScore W1570452496C132901563 @default.
- W1570452496 hasConceptScore W1570452496C134018914 @default.
- W1570452496 hasConceptScore W1570452496C150194340 @default.
- W1570452496 hasConceptScore W1570452496C153911025 @default.
- W1570452496 hasConceptScore W1570452496C172680121 @default.
- W1570452496 hasConceptScore W1570452496C177707886 @default.
- W1570452496 hasConceptScore W1570452496C181199279 @default.
- W1570452496 hasConceptScore W1570452496C2779234561 @default.
- W1570452496 hasConceptScore W1570452496C2781330172 @default.
- W1570452496 hasConceptScore W1570452496C28859421 @default.
- W1570452496 hasConceptScore W1570452496C54355233 @default.
- W1570452496 hasConceptScore W1570452496C55493867 @default.
- W1570452496 hasConceptScore W1570452496C71924100 @default.
- W1570452496 hasConceptScore W1570452496C86803240 @default.
- W1570452496 hasIssue "32" @default.
- W1570452496 hasLocation W15704524961 @default.
- W1570452496 hasOpenAccess W1570452496 @default.
- W1570452496 hasPrimaryLocation W15704524961 @default.
- W1570452496 hasRelatedWork W132592907 @default.
- W1570452496 hasRelatedWork W1603103450 @default.
- W1570452496 hasRelatedWork W1775749144 @default.
- W1570452496 hasRelatedWork W1803433400 @default.
- W1570452496 hasRelatedWork W1848523579 @default.