Matches in SemOpenAlex for { <https://semopenalex.org/work/W1570457166> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W1570457166 endingPage "205" @default.
- W1570457166 startingPage "199" @default.
- W1570457166 abstract "Adenosine phosphorylase (adenosine: orthophosphate ribosyltransferase) activity is low in mammalian cells, but is abundant in certain prokaryotes. It is an appropriate target enzyme for the development of diagnostic and chemotherapeutic agents. Adenosine phosphorylase from Bacillus subtilis and mycoplasmas that commonly infect cell cultures converted the non-toxic deoxyadenosine analog, 6-methylpurine deoxyriboside (6MPDR) into the potent anti-metabolites 6-methylpurine and 6-methylpurine riboside. Consequently 6MPDR selectively killed mammalian cell cultures infected with mycoplasmas. 6MPDR was cytotoxic to 87 of 90 mycoplasma-infected cultures (96.6%). No toxicity was observed in nine different types of mycoplasma-free cell cultures. Use of a 3T6 mouse embryo fibroblast indicator cell culture improved standardization. Cytotoxicity was apparent 3–4 days after inoculation of 10 μM of 6MPDR to 3T6 cultures infected with the following mycoplasmas: M. hyorhinis, M. orale, M. arginini, M. salivarium, A, laidlawii, M. hominis, M. fermentons, M. sp. 70–159 and M. buccale. Cytotoxicity was produced in 28/28 3T6 indicator cultures inoculated with mycoplasma-infected cell cultures in the presence of 10 μM 6MPDR. The analog is apparently non-toxic to the mycoplasmas." @default.
- W1570457166 created "2016-06-24" @default.
- W1570457166 creator A5058665812 @default.
- W1570457166 creator A5086448751 @default.
- W1570457166 date "1982-05-01" @default.
- W1570457166 modified "2023-09-27" @default.
- W1570457166 title "Adenosine phosphorylase-mediated nucleoside toxicity" @default.
- W1570457166 cites W103819310 @default.
- W1570457166 cites W1419273957 @default.
- W1570457166 cites W1572431390 @default.
- W1570457166 cites W2004285483 @default.
- W1570457166 cites W2020841665 @default.
- W1570457166 cites W2023855032 @default.
- W1570457166 cites W2026637926 @default.
- W1570457166 cites W2035913814 @default.
- W1570457166 cites W2051511207 @default.
- W1570457166 cites W2055499537 @default.
- W1570457166 cites W2067259836 @default.
- W1570457166 cites W2208697656 @default.
- W1570457166 doi "https://doi.org/10.1016/0014-4827(82)90333-0" @default.
- W1570457166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6806107" @default.
- W1570457166 hasPublicationYear "1982" @default.
- W1570457166 type Work @default.
- W1570457166 sameAs 1570457166 @default.
- W1570457166 citedByCount "94" @default.
- W1570457166 countsByYear W15704571662013 @default.
- W1570457166 countsByYear W15704571662014 @default.
- W1570457166 countsByYear W15704571662015 @default.
- W1570457166 countsByYear W15704571662018 @default.
- W1570457166 countsByYear W15704571662022 @default.
- W1570457166 crossrefType "journal-article" @default.
- W1570457166 hasAuthorship W1570457166A5058665812 @default.
- W1570457166 hasAuthorship W1570457166A5086448751 @default.
- W1570457166 hasConcept C109316439 @default.
- W1570457166 hasConcept C153911025 @default.
- W1570457166 hasConcept C181199279 @default.
- W1570457166 hasConcept C202751555 @default.
- W1570457166 hasConcept C2776476023 @default.
- W1570457166 hasConcept C2776543447 @default.
- W1570457166 hasConcept C2776991684 @default.
- W1570457166 hasConcept C2778838687 @default.
- W1570457166 hasConcept C54355233 @default.
- W1570457166 hasConcept C55493867 @default.
- W1570457166 hasConcept C71615608 @default.
- W1570457166 hasConcept C81885089 @default.
- W1570457166 hasConcept C86803240 @default.
- W1570457166 hasConcept C89423630 @default.
- W1570457166 hasConceptScore W1570457166C109316439 @default.
- W1570457166 hasConceptScore W1570457166C153911025 @default.
- W1570457166 hasConceptScore W1570457166C181199279 @default.
- W1570457166 hasConceptScore W1570457166C202751555 @default.
- W1570457166 hasConceptScore W1570457166C2776476023 @default.
- W1570457166 hasConceptScore W1570457166C2776543447 @default.
- W1570457166 hasConceptScore W1570457166C2776991684 @default.
- W1570457166 hasConceptScore W1570457166C2778838687 @default.
- W1570457166 hasConceptScore W1570457166C54355233 @default.
- W1570457166 hasConceptScore W1570457166C55493867 @default.
- W1570457166 hasConceptScore W1570457166C71615608 @default.
- W1570457166 hasConceptScore W1570457166C81885089 @default.
- W1570457166 hasConceptScore W1570457166C86803240 @default.
- W1570457166 hasConceptScore W1570457166C89423630 @default.
- W1570457166 hasIssue "1" @default.
- W1570457166 hasLocation W15704571661 @default.
- W1570457166 hasLocation W15704571662 @default.
- W1570457166 hasOpenAccess W1570457166 @default.
- W1570457166 hasPrimaryLocation W15704571661 @default.
- W1570457166 hasRelatedWork W1504841080 @default.
- W1570457166 hasRelatedWork W1514853126 @default.
- W1570457166 hasRelatedWork W1526669333 @default.
- W1570457166 hasRelatedWork W2038622193 @default.
- W1570457166 hasRelatedWork W2039977243 @default.
- W1570457166 hasRelatedWork W2050260058 @default.
- W1570457166 hasRelatedWork W2060064436 @default.
- W1570457166 hasRelatedWork W2412547646 @default.
- W1570457166 hasRelatedWork W2442340209 @default.
- W1570457166 hasRelatedWork W87191576 @default.
- W1570457166 hasVolume "139" @default.
- W1570457166 isParatext "false" @default.
- W1570457166 isRetracted "false" @default.
- W1570457166 magId "1570457166" @default.
- W1570457166 workType "article" @default.