FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1570505030> ?p ?o ?g. }

• W1570505030 endingPage "7452" @default.
• W1570505030 startingPage "7444" @default.
• W1570505030 abstract "In addition to its role as a CNS neurotransmitter, glutamate has been shown recently to be an important component of the peripheral inflammation response. We demonstrated previously that the group I metabotropic glutamate receptors (mGluRs) mGlu1 and mGlu5 are expressed in the peripheral terminals of sensory neurons and that activation of group I mGluRs in the skin increases thermal sensitivity. In the present study, we provide evidence suggesting that group I mGluRs increase thermal sensitivity by enhancing vanilloid (capsaicin) receptor function. We show that mGlu5 potentiates capsaicin responses in mouse sensory neurons by the phospholipase C pathway but not by activation of protein kinase C. Rather, the effects are mediated by the metabolism of diacylglycerol and the production of prostaglandins via the cyclooxygenase pathway, leading to activation of the cAMP-dependent protein kinase subsequent to prostanoid receptor activation. Behavioral thermal sensitization in mice induced by intraplantar injection of mGlu1/5 agonists was also blocked by inhibitors of protein kinase A and cyclooxygenase, suggesting that a similar signaling pathway operates<i>in vivo</i>. These results demonstrate a novel signaling pathway in sensory neurons and provide a plausible mechanism for the enhancement of thermal sensitivity that occurs with inflammation and after activation of mGluRs on peripheral sensory neuron terminals." @default.
• W1570505030 created "2016-06-24" @default.
• W1570505030 creator A5006363718 @default.
• W1570505030 creator A5018956141 @default.
• W1570505030 creator A5068387021 @default.
• W1570505030 date "2002-09-01" @default.
• W1570505030 modified "2023-09-24" @default.
• W1570505030 title "Prostaglandin and Protein Kinase A-Dependent Modulation of Vanilloid Receptor Function by Metabotropic Glutamate Receptor 5: Potential Mechanism for Thermal Hyperalgesia" @default.
• W1570505030 cites W1511198581 @default.
• W1570505030 cites W1564453175 @default.
• W1570505030 cites W1571969265 @default.
• W1570505030 cites W1600528148 @default.
• W1570505030 cites W1916850619 @default.
• W1570505030 cites W1950417202 @default.
• W1570505030 cites W1952328179 @default.
• W1570505030 cites W1964581140 @default.
• W1570505030 cites W1968032237 @default.
• W1570505030 cites W1973556415 @default.
• W1570505030 cites W1976408536 @default.
• W1570505030 cites W1978860160 @default.
• W1570505030 cites W1982014607 @default.
• W1570505030 cites W1985030046 @default.
• W1570505030 cites W1991477055 @default.
• W1570505030 cites W1991589842 @default.
• W1570505030 cites W1992779373 @default.
• W1570505030 cites W1995705528 @default.
• W1570505030 cites W2010159487 @default.
• W1570505030 cites W2020224671 @default.
• W1570505030 cites W2026106464 @default.
• W1570505030 cites W2028570768 @default.
• W1570505030 cites W2028985025 @default.
• W1570505030 cites W2038777222 @default.
• W1570505030 cites W2039275254 @default.
• W1570505030 cites W2046983269 @default.
• W1570505030 cites W2049100687 @default.
• W1570505030 cites W2050153206 @default.
• W1570505030 cites W2050781058 @default.
• W1570505030 cites W2052709505 @default.
• W1570505030 cites W2062671000 @default.
• W1570505030 cites W2081901423 @default.
• W1570505030 cites W2084741333 @default.
• W1570505030 cites W2085360390 @default.
• W1570505030 cites W2121612337 @default.
• W1570505030 cites W2128640372 @default.
• W1570505030 cites W2134742719 @default.
• W1570505030 cites W2166086438 @default.
• W1570505030 cites W2195049256 @default.
• W1570505030 cites W2400059367 @default.
• W1570505030 doi "https://doi.org/10.1523/jneurosci.22-17-07444.2002" @default.
• W1570505030 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6757997" @default.
• W1570505030 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12196566" @default.
• W1570505030 hasPublicationYear "2002" @default.
• W1570505030 type Work @default.
• W1570505030 sameAs 1570505030 @default.
• W1570505030 citedByCount "177" @default.
• W1570505030 countsByYear W15705050302012 @default.
• W1570505030 countsByYear W15705050302013 @default.
• W1570505030 countsByYear W15705050302014 @default.
• W1570505030 countsByYear W15705050302015 @default.
• W1570505030 countsByYear W15705050302016 @default.
• W1570505030 countsByYear W15705050302017 @default.
• W1570505030 countsByYear W15705050302018 @default.
• W1570505030 countsByYear W15705050302019 @default.
• W1570505030 countsByYear W15705050302020 @default.
• W1570505030 countsByYear W15705050302021 @default.
• W1570505030 countsByYear W15705050302022 @default.
• W1570505030 crossrefType "journal-article" @default.
• W1570505030 hasAuthorship W1570505030A5006363718 @default.
• W1570505030 hasAuthorship W1570505030A5018956141 @default.
• W1570505030 hasAuthorship W1570505030A5068387021 @default.
• W1570505030 hasBestOaLocation W15705050301 @default.
• W1570505030 hasConcept C119128870 @default.
• W1570505030 hasConcept C169760540 @default.
• W1570505030 hasConcept C170493617 @default.
• W1570505030 hasConcept C185592680 @default.
• W1570505030 hasConcept C200385062 @default.
• W1570505030 hasConcept C207951395 @default.
• W1570505030 hasConcept C26702167 @default.
• W1570505030 hasConcept C2775908076 @default.
• W1570505030 hasConcept C41653306 @default.
• W1570505030 hasConcept C49051014 @default.
• W1570505030 hasConcept C55493867 @default.
• W1570505030 hasConcept C61174792 @default.
• W1570505030 hasConcept C86803240 @default.
• W1570505030 hasConcept C95444343 @default.
• W1570505030 hasConcept C98274493 @default.
• W1570505030 hasConceptScore W1570505030C119128870 @default.
• W1570505030 hasConceptScore W1570505030C169760540 @default.
• W1570505030 hasConceptScore W1570505030C170493617 @default.
• W1570505030 hasConceptScore W1570505030C185592680 @default.
• W1570505030 hasConceptScore W1570505030C200385062 @default.
• W1570505030 hasConceptScore W1570505030C207951395 @default.
• W1570505030 hasConceptScore W1570505030C26702167 @default.
• W1570505030 hasConceptScore W1570505030C2775908076 @default.
• W1570505030 hasConceptScore W1570505030C41653306 @default.
• W1570505030 hasConceptScore W1570505030C49051014 @default.
• W1570505030 hasConceptScore W1570505030C55493867 @default.
• W1570505030 hasConceptScore W1570505030C61174792 @default.

• next