Matches in SemOpenAlex for { <https://semopenalex.org/work/W157050755> ?p ?o ?g. }
Showing items 1 to 65 of
65
with 100 items per page.
- W157050755 abstract "In this thesis I examined vascular physiology, with an emphasis on venousphysiology, of two important neuro-hormones, aldosterone and bradykinin, in healthand in chronic heart failure. Capacitance venous tone governs the volume of blood inthe peripheral vs. central circulation and thus indirectly influences cardiac output.Mechanisms that control venous tone in health and in heart failure are poorlyunderstood. Chapter 1 discusses the importance of venous physiology in governing cardiac outputin health and heart failure. The significance of pressure volume relationships, ratherthan pressure flow relationships in capacitance veins is explained. The physiologicalmeasures and the terms used to describing changes in parameters are defined. Chapter 2 is a literature review of pharmacology and physiology of aldosterone andbradykinin, with an emphasis on vascular physiology in health and in chronic heartfailure. Chapter 3 describes in detail our methods of assessing both resistance and capacitancevascular functions. It examines changes to vasculature with a semi-supine posture,relationship between arterial flow and venous capacitance, and compares twoestablished techniques in assessing capacitance veins. Chapter 4, 5 and 6 examines in detail the effects of aldosterone and bradykinin onhuman forearm vasculature, and differences in vascular responses between states ofhealth and heart failure are discussed. The important new findings of this thesis are: 1. In physiological concentrations, aldosterone does not acutely alter vascularphysiology in health. 2. In contrast, in treated heart failure aldosterone decreases blood flow inresistance vessels but not in capacitance vessels 3. Bradylcinin modulates venous capacitance in health via its Type 2 receptor.However, bradykinin does not contribute to basal vascular tone in health 4. In angiotensin-converting-enzyme-inhibitor-treated heart failure, bradykinincontributes to basal venous tone. In contrast, bradykinin does not contribute tovenous tone in heart failure treated with angiotensin II receptor antagonists. 5. In mild to moderate heart failure bradykinin effects are mediated via the Type2 Bradykinin receptor. 6. A paradoxical enhanced venodilatation was discovered in heart failure patientson both aspirin and angiotensin converting enzyme inhibitors, in comparisonto those only on the latter." @default.
- W157050755 created "2016-06-24" @default.
- W157050755 creator A5009828055 @default.
- W157050755 date "2008-01-01" @default.
- W157050755 modified "2023-09-27" @default.
- W157050755 title "Venous physiology of aldosterone and bradykinin in health and chronic heart failure" @default.
- W157050755 hasPublicationYear "2008" @default.
- W157050755 type Work @default.
- W157050755 sameAs 157050755 @default.
- W157050755 citedByCount "0" @default.
- W157050755 crossrefType "dissertation" @default.
- W157050755 hasAuthorship W157050755A5009828055 @default.
- W157050755 hasConcept C126322002 @default.
- W157050755 hasConcept C139940330 @default.
- W157050755 hasConcept C164705383 @default.
- W157050755 hasConcept C170493617 @default.
- W157050755 hasConcept C178853913 @default.
- W157050755 hasConcept C183683566 @default.
- W157050755 hasConcept C2778198053 @default.
- W157050755 hasConcept C2778525890 @default.
- W157050755 hasConcept C2779591629 @default.
- W157050755 hasConcept C47323905 @default.
- W157050755 hasConcept C58245268 @default.
- W157050755 hasConcept C71924100 @default.
- W157050755 hasConcept C84393581 @default.
- W157050755 hasConceptScore W157050755C126322002 @default.
- W157050755 hasConceptScore W157050755C139940330 @default.
- W157050755 hasConceptScore W157050755C164705383 @default.
- W157050755 hasConceptScore W157050755C170493617 @default.
- W157050755 hasConceptScore W157050755C178853913 @default.
- W157050755 hasConceptScore W157050755C183683566 @default.
- W157050755 hasConceptScore W157050755C2778198053 @default.
- W157050755 hasConceptScore W157050755C2778525890 @default.
- W157050755 hasConceptScore W157050755C2779591629 @default.
- W157050755 hasConceptScore W157050755C47323905 @default.
- W157050755 hasConceptScore W157050755C58245268 @default.
- W157050755 hasConceptScore W157050755C71924100 @default.
- W157050755 hasConceptScore W157050755C84393581 @default.
- W157050755 hasLocation W1570507551 @default.
- W157050755 hasOpenAccess W157050755 @default.
- W157050755 hasPrimaryLocation W1570507551 @default.
- W157050755 hasRelatedWork W127089599 @default.
- W157050755 hasRelatedWork W131118871 @default.
- W157050755 hasRelatedWork W143924748 @default.
- W157050755 hasRelatedWork W1992985106 @default.
- W157050755 hasRelatedWork W2016768719 @default.
- W157050755 hasRelatedWork W2022845792 @default.
- W157050755 hasRelatedWork W2030043227 @default.
- W157050755 hasRelatedWork W2112224560 @default.
- W157050755 hasRelatedWork W2260603754 @default.
- W157050755 hasRelatedWork W2400575750 @default.
- W157050755 hasRelatedWork W2402761767 @default.
- W157050755 hasRelatedWork W2404182781 @default.
- W157050755 hasRelatedWork W2412782030 @default.
- W157050755 hasRelatedWork W2413836257 @default.
- W157050755 hasRelatedWork W2415277945 @default.
- W157050755 hasRelatedWork W2476475156 @default.
- W157050755 hasRelatedWork W36184483 @default.
- W157050755 hasRelatedWork W39767427 @default.
- W157050755 hasRelatedWork W773439615 @default.
- W157050755 hasRelatedWork W2315380910 @default.
- W157050755 isParatext "false" @default.
- W157050755 isRetracted "false" @default.
- W157050755 magId "157050755" @default.
- W157050755 workType "dissertation" @default.