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- W1570518269 startingPage "546" @default.
- W1570518269 abstract "HIV devotes a large portion of its coding capacity to counteracting the function of mammalian antiviral proteins. Landau and colleagues discuss the biology of mammalian restriction factors and the viral accessory proteins that counteract them. To replicate in their hosts, viruses have to navigate the complexities of the mammalian cell, co-opting mechanisms of cellular physiology while defeating restriction factors that are dedicated to halting their progression. Primate lentiviruses devote a relatively large portion of their coding capacity to counteracting restriction factors by encoding accessory proteins dedicated to neutralizing the antiviral function of these intracellular inhibitors. Research into the roles of the accessory proteins has revealed the existence of previously undetected intrinsic defenses, provided insight into the evolution of primate lentiviruses as they adapt to new species and uncovered new targets for the development of therapeutics. This Review discusses the biology of the restriction factors APOBEC3, SAMHD1 and tetherin and the viral accessory proteins that counteract them." @default.
- W1570518269 created "2016-06-24" @default.
- W1570518269 creator A5036106449 @default.
- W1570518269 creator A5055612606 @default.
- W1570518269 creator A5059030967 @default.
- W1570518269 date "2015-05-19" @default.
- W1570518269 modified "2023-10-11" @default.
- W1570518269 title "Intrinsic host restrictions to HIV-1 and mechanisms of viral escape" @default.
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